Shaanxi University of Chinese Medicine

Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy

Abstract Ulcerative colitis (UC) is characterized by persistent colonic inflammation accompanied by the accumulation of pro-inflammatory M1-like macrophages, which sustain cytokine production and impair mucosal repair. Promoting a shift toward a pro-resolving M2-like phenotype is...

YouTube, TikTok, and Bilibili as sources of medical information on lumbar spinal stenosis

Lumbar spinal stenosis (LSS) is a common degenerative condition that impairs mobility and quality of life, particularly in older adults. Video-sharing platforms are increasingly used for health information, yet the quality and reliability of LSS-related videos and cross-platform...

Latency-efficient cloud-edge cultural pattern generation via lossless lightweight condition transmission and bandwidth-adaptive scheduling

Abstract Cloud-edge systems for controllable diffusion generation typically upload the raw reference image, although ControlNet consumes only a sparse structural condition derived from it. We present a cloud-edge framework for directed cultural pattern generation in which the edg...

Quality Difference Analysis of Raw and Wine‐Processed Polygonati Rhizoma Based on Correlation Between Color and Component

ABSTRACT The dried rhizome of Polygonati Rhizoma, known as Huangjing, is commonly used clinically in both its raw and wine‐processed forms. However, the distinctions in quality between them remain unclear, and the methods for identifying them are considerably intricate. This stud...

Tumor-intrinsic SIRPα drives anti-PD-1 resistance in esophageal cancer by coordinating proliferative dominance and T-cell exhaustion: A target for combinatorial immunotherapy

Signal regulatory protein alpha (SIRPα) is a novel immune checkpoint protein. However, the role and mechanism of SIRPα in esophageal cancer (ESCA) remain unclear. This study explores the role of tumor intrinsic SIRPα in ESCA. Twenty-one ESCA samples treated or not with anti-progr...

Analysis of Blood Components of Xiangju Tablets Based on UPLC‐QTOF‐MS/MS and Network Pharmacology

ABSTRACT Based on serum pharmacochemistry and network pharmacology, the pharmacodynamic material basis and mechanism of Xiangju tablets (XJPs) in the treatment of rhinitis and sinusitis were discussed. UPLC‐QTOF‐MS/MS technology combined with Compound Discover 3.0 was used to ana...

Single-Cell Transcriptomic Profiling of the O -Methyltransferase Characteristics of Flavonoid Biosynthesis in Ziziphus jujuba var. spinosa Fruit

Abstract Sour jujube (Ziziphus jujuba var. spinosa) is a valuable medicinal and edible fruit owing to its health-promoting properties. Methoxylated flavonoids enhance their value by improving stability and bioavailability. However, the cellular basis of their biosynthesis remains...

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Pathological cartilage calcification represents a pivotal pathological alteration in osteoarthritis (OA), yet its underlying mechanisms remain poorly understood. Exosomes are involved in facilitating calcification, and their biogenesis may be linked to autophagy disruption. Howev...

Iron‐Sulfur Cluster Targeting: A Novel Perspective for Treating Alcohol‐Related Lipid Metabolic Diseases

ABSTRACT Iron–sulfur (Fe–S) clusters are pivotal molecular cofactors bridging inorganic chemistry and organic life processes, with their tightly regulated biosynthesis and function underpinning cellular metabolic homeostasis. Chronic alcohol‐induced metabolic stress impairs Fe–S...

Latent profile analysis of postpartum depression symptoms and its associations with weight stigma and eating behaviors among postpartum women in China

Abstract Background Postpartum depression (PPD) represents a significant maternal health challenge with diverse symptom manifestations. Traditional analytical approaches that treat postpartum women as a homogeneous group may obscure distinct symptom patterns, limiting the develop...