Severance Hospital

Clinical Outcomes of Switching from Prostaglandin Analogs to Omidenepag Isopropyl in Primary Open-Angle Glaucoma and Glaucoma Suspect Patients with Prostaglandin-Associated Periorbitopathy: A Prospective, Multicenter Study

Background/Objectives: Prostaglandin-associated periorbitopathy (PAP) is a common treatment-related burden of prostaglandin analog (PGA) therapy that may compromise long-term glaucoma management. This study evaluated improvement in PAP and changes in intraocular pressure (IOP) af...

Association of Estimated Arterial Stiffness with Collateral Status and Functional Outcome after Endovascular Thrombectomy: A Secondary Analysis of the OPTIMAL-BP Trial

PURPOSE: Estimated pulse wave velocity (ePWV) is a surrogate of arterial stiffness that may influence stroke outcomes and potentially affect collateral circulation. We examined the association of ePWV with collateral status and 3-month functional outcome after successful endovasc...

Early Mitral Valve Surgery and Survival in Asymptomatic Severe Primary Mitral Regurgitation

Importance The optimal timing of mitral valve (MV) surgery in patients with asymptomatic severe primary mitral regurgitation (MR) remains uncertain because randomized clinical trials are lacking. Objective To evaluate the association of early MV surgery with long-term survival in...

The Effect of Covert Narcissism on Relationship Addiction in Early Adulthood: The Double Mediating Effects of Distress Tolerance and Emotion Dysregulation

Background: This study examined the pathway through which covert narcissism leads to relationship addiction through distress tolerance and emotion dysregulation in early adulthood.Methods: Data were collected from 394 Korean adults aged 18–39 years who were recruited using online...

Contrasting Prognostic Value of Discordance Between Resting Distal-to-Aortic Coronary Pressure Ratio and Fractional Flow Reserve in Coronary Artery Disease

BACKGROUND: Discordance between nonhyperemic pressure ratios and fractional flow reserve (FFR), observed in up to 20% of cases, complicates clinical decision-making for coronary revascularization and warrants further investigation of its clinical implications. This study aimed to...

Survival impact of repeated endobiliary radiofrequency ablation in patients undergoing durvalumab plus gemcitabine and cisplatin for extrahepatic cholangiocarcinoma (BRAVE trial): study protocol for an international multicenter randomized controlled trial

Extrahepatic cholangiocarcinoma (eCCA) often presents with unresectable disease and obstructive jaundice. Systemic therapy with gemcitabine–cisplatin plus durvalumab (GCD) is an international standard; however, the median overall survival (OS) remains about 1 year. Endobiliary ra...

Beyond conventional immunosuppression: tailoring perioperative management protocols for clinical xenotransplantation

Clinical xenotransplantation offers a conceptually unlimited supply of donor organs, owing to transformative advances in gene-editing technologies. However, the pharmacological and physiological distinctions between allo- and xenotransplantation pose a major challenge. Unlike all...

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to...

Delayed diagnosis and brain biopsy in central nervous system intravascular large B-cell lymphoma: a three-patient case series

Central nervous system intravascular large B-cell lymphoma (CNS IVLBCL) is a rare, aggressive lymphoma that can mimic inflammatory, infectious, demyelinating, and vascular disorders.We describe three patients with pathologically confirmed CNS IVLBCL who presented with progressive...

A refined MASH–HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression

Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as a leading driver of hepatocellular carcinoma (HCC), yet the molecular mechanisms linking metabolic stress, chronic inflammation and tumorigenesis remain poorly understood. Here we established a metabo...

Noninvasive surrogate endpoints in MASH trials: current perspectives and challenges

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of cirrhosis and liver-related morbidity. Current regulatory pathways rely on histology and long-term clinical outcomes, but repeated liver biopsy is noninvasive and poorly reproducible...

Optimal gating envelope size for automatic gating in magnetic resonance imaging–guided radiotherapy

Purpose This study aimed to investigate the optimal gating envelope (GE) size for automatic gating in magnetic resonance imaging–guided radiotherapy (MRIgRT) for liver cancer. Methods This study retrospectively analyzed imaging and radiation treatment data from ten patients with...

Three-Year Outcomes of Drug-Eluting Stents, Drug-Coated Balloons, and Non-Drug-Eluting Devices in Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry

Background: Although drug-eluting devices have demonstrated improved efficacy in femoropopliteal artery (FPA) disease, evidence on their long-term clinical outcomes in realworld practice remains limited.Methods: Using data from the multicenter Korean Vascular Intervention Society...

Chronic ER stress couples cellular senescence with pigment retention

Solar lentigines are characterized by persistent basal hyperpigmentation. We hypothesized that chronic IRE1α-mediated ER stress simultaneously increases melanocyte melanogenesis and impairs keratinocyte melanophagic clearance, generating a pigment-retention state. We analyzed pai...

Preferences and reasons for clothing colors in women patients and survivors of breast cancer in Korea

Purpose Clothing color can affect the psychological aspects in female patients and survivors of breast cancer; however, little is known regarding their preferences and reasons for choosing specific clothing color. This study aimed to explore the factors influencing their clothing...

Genomic Reanalysis of Neurodevelopmental Disorders With and Without Epilepsy: Diagnostic Yield and Mechanisms of Newly Established Diagnoses

Background/Objectives: Genomic reanalysis may provide additional molecular diagnoses in patients with neurodevelopmental disorders (NDDs) whose initial genetic testing was nondiagnostic. We evaluated the diagnostic yield and mechanisms of newly established diagnoses in NDDs with...

Predictors of Early Versus Late Atrial Tachyarrhythmia Recurrence After Cryoballoon Ablation by Atrial Fibrillation Type

ABSTRACT Introduction Patient characteristics and predictors of early (ERAT) and late (LRAT) recurrence of atrial tachyarrhythmia by atrial fibrillation (AF) type after cryoballoon ablation (CBA) remain poorly defined. Methods Using the Korean Heart Rhythm Cryoballoon Registry (1...

Prognostic Score Model for 30-Day Mortality in Patients with Acute Pulmonary Embolism Presenting to the Emergency Department

Background/Objectives: Early risk stratification is essential in pulmonary embolism (PE), but a simple tool integrating routinely available clinical and laboratory variables is lacking. We aimed to develop a simple score for predicting 30-day mortality in patients presenting to t...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Quantitative Analysis of Automatically Segmented Perivascular Space in Subcortical White Matter of Parkinson’s Disease: Its Clinical Relevance

Objective: To examine the relationship between automatically quantified perivascular space (PVS) extent located in the subcortical white matter (WM), baseline motor deficits and cognitive function, as well as longitudinal motor and cognitive outcomes in patients with Parkinson's...