Seventh People's Hospital of Shanghai

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

Latent profile analysis of stigma and medical coping among patients with vaginitis: a cross-sectional study

Vaginitis is a common chronic condition among genital tract infections. Its sensitive anatomical location and tendency to recur not only impact individual health but also affect psychological well-being and coping strategies. This study aimed to identify latent profiles of stigma...

Toxic effects of streptozotocin (STZ)-induced zebrafish and the response mechanism of liver transcriptome

Streptozotocin (STZ) is commonly used to induce diabetes, but its efficacy and systemic toxicity in zebrafish remain controversial. This study evaluated the dose-dependent effects of STZ in adult zebrafish and explored the molecular mechanisms underlying hepatotoxicity using tran...