Seventh People's Hospital of Shanghai

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, w...

Persistent Hypoperfusion on Post‐Recanalization Digital Subtraction Angiography Perfusion Maps in Anterior Circulation Large Vessel Occlusion

Background Despite high recanalization rates with endovascular thrombectomy for large vessel occlusion stroke, a large proportion of patients remain disabled. This study aims to investigate the clinical impact of persistent hypoperfusion that was detected immediately after recana...

National Epidemiological Trends in Hepatitis A–E Serologic and Virologic Markers in the United States, 2011–2023: A Population-Based Study

Viral hepatitis caused by A to E imposes a substantial global burden of liver disease. Despite US control strategies, long-term national data covering serologic markers of all five hepatitis viruses remain limited. In this study, we analyzed epidemiologic trends from 2011 to 2023...

Intelligent multimodal classification of infantile vascular diseases based on ultrasound images

Infantile hemangiomas (IH) and venous malformations (VMs) often exhibit overlapping echogenic features in grayscale ultrasound images, necessitating color Doppler ultrasound for accurate diagnosis. Furthermore, some venous malformation patients develop painful phleboliths (vein s...

Atractylodis Rhizoma-derived nanovesicles suppress adipocyte IDO1/kynurenine-AhR-androgen receptor signaling in a mouse model of obesity-associated PCOS

Abstract Background Obesity-associated polycystic ovary syndrome (PCOS) is characterized by metabolic dysfunction, adipose inflammation and androgen excess, but the adipose mechanism linking metabolic stress to androgen-related pathology remains unclear. This study aimed to deter...

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

Latent profile analysis of stigma and medical coping among patients with vaginitis: a cross-sectional study

Vaginitis is a common chronic condition among genital tract infections. Its sensitive anatomical location and tendency to recur not only impact individual health but also affect psychological well-being and coping strategies. This study aimed to identify latent profiles of stigma...

Toxic effects of streptozotocin (STZ)-induced zebrafish and the response mechanism of liver transcriptome

Streptozotocin (STZ) is commonly used to induce diabetes, but its efficacy and systemic toxicity in zebrafish remain controversial. This study evaluated the dose-dependent effects of STZ in adult zebrafish and explored the molecular mechanisms underlying hepatotoxicity using tran...