Sendai Kousei Hospital

Differences in Biological Responses to Ultra-high Dose Rate Proton Irradiation Between Entrance and SOBP Regions In Vitro

Background/Aim: Ultra-high dose rate (FLASH) radiotherapy has been reported to reduce normal tissue toxicity while maintaining tumor control. However, whether proton FLASH induces different biological responses in the entrance versus spread-out Bragg peak (SOBP) regions under con...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...