Second People's Hospital of Yunnan Province

The Conversion of Black Chokeberry Condensed Tannins into Anthocyanidins Has a Better Reparative Effect on the Imbalance of Gut Microbiota and Metabolites Caused by a High-Salt Diet

Abstract Black chokeberry is rich in polyphenols, but its high-content polymeric condensed tannins impair gut microbiota, while anthocyanins exert beneficial regulatory effects. This study compared the reparative effects and metabolic changes of black chokeberry extracts (BCE: ri...

Differential modulation of ferroptosis pathways by NOX1/4 and NLRP3 inhibition in DSS-induced colitis

Ferroptosis contributes to the pathogenesis of inflammatory bowel disease, but how NOX1/4 and NLRP3 pathways regulate this process remains unclear. This study aimed to investigate the therapeutic effects and mechanisms of the NOX1/4 inhibitor Setanaxib (SET) and the NLRP3 inhibit...

Machine learning prediction of SIRS after percutaneous nephrolithotomy in older adults: role of frailty, malnutrition, and sarcopenia

Systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PCNL) is a critical complication in older adults. However, the impact of frailty, malnutrition, and sarcopenia (F-M-S) comorbidity on postoperative SIRS remains unclear. This study aimed to evaluat...

Decoupling Ecological and Pathogenic Roles: Helicobacter pylori as a Gastric Hegemon Maintaining Order or Amplifying Dysbiotic Chaos

Abstract Gastric dysbiosis refers to disease-associated alterations in microbial composition and between-individual variability. We postulate that Helicobacter pylori (H. pylori or Hp) exerts a context-dependent ecological effect across the Correa cascade—the histopathological pr...

Correlation analysis between Helicobacter pylori antibody typing and endoscopic classification of chronic atrophic gastritis and OLGA/OLGIM staging

Abstract Background and aim : Chronic atrophic gastritis (CAG) is a well-established precancerous condition in the gastric carcinogenesis cascade. Helicobacter pylori (Hp) infection is the primary etiological factor for CAG; however, the differential impact of Hp virulence types...

Liver cancer stem cells drive hepatocellular carcinoma progression and therapeutic resistance

Hepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy worldwide, with persistently high rates of therapeutic resistance and post-treatment recurrence. Liver cancer stem cells (LCSCs), a distinct subpopulation of cancer cells endowed with stem cell-like proper...

Exploration and practice of a DeepSeek‑enhanced, scenario‑based teaching model integrated with a multidisciplinary team approach in gastroenterology residency training

The first year of standardised residency training is a critical transition from medical student to clinical practitioner, during which trainees struggle to integrate theoretical knowledge with clinical competencies. Traditional teaching often lacks active learning and authentic c...