Second People’s Hospital of Yibin

Identification of key signature genes and construction of a diagnostic model for heart failure based on integrative transcriptomic and eQTL-based analyses and single‑cell eQTL Mendelian randomization

Heart failure (HF) is a life-threatening end-stage syndrome of cardiovascular disease with a rapidly increasing global incidence. Its underlying biological mechanisms remain unclear, and current biomarkers lack sufficient diagnostic accuracy. Single-cell eQTLs and Mendelian rando...

A meta-analysis of the effects of Zingiber officinale on metabolic indices among patients with type 2 diabetes

Abstract The metabolic effects of ginger ( Zingiber officinale ) on type 2 diabetes have been increasingly assessed in clinical trials, but the results remain inconsistent. In this updated meta-analysis, the Cochrane Library, Scopus, PubMed, Web of Science, and Google Scholar wer...

Depressive Symptoms, sleep Disturbance, and Cardiometabolic Multimorbidity Among Adults With Arthritis: A Cross‐Sectional Analysis of NHANES 2013–2020

While the association between depressive symptoms and cardiometabolic disease is well established, the relationships among depressive symptoms, sleep disturbance, and cardiometabolic multimorbidity (CMM) in adults with arthritis remain insufficiently understood. This cross-sectio...

The cGAS-STING pathway in acute myocardial infarction: Biomarker discovery and mechanistic insights

Acute Myocardial infarction (AMI) continues to be a severe deadly disease with a high case-fatality rate and great psychological and economic costs. Despite the development of new therapies, early diagnosis and treatment optimization still are problematical. Here we applied the i...

Acute kidney injury following ingestion of Amanita section Roanokenses in Yunnan, China: a five-case clinico-toxicological series

Introduction Amanita section Roanokenses is a major cause of mushroom-related acute kidney injury in China, but detailed clinico-toxicological case series remain scarce. We retrospectively analyzed five acute kidney injury cases attributed to this section in Yunnan, China, from 2...

Dynamic association between gut microbiota succession and host metabolism: differential effects of antibiotic intervention duration on glucose and lipid metabolism in high-fat diet-induced obese mice

Abstract Background The gut microbiota plays a critical role in the onset and progression of obesity. Previous studies have indicated that antibiotic administration may influence host physiology and pathology by modulating the gut microbiota. However, whether different durations...

Kaempferol as a dietary guardian against gastric carcinogenesis: Breaking the Correa's cascade at multiple junctions

Correa's cascade outlines the dynamic progression of gastric carcinogenesis, from chronic non-atrophic gastritis (CNAG) to chronic atrophic gastritis (CAG), gastric precancerous lesions, and finally gastric cancer (GC). A natural compound, kaempferol (KAE), abundant in many fruit...

Validation of Newcastle ENDOPREM for assessing patient experience with colonoscopy: a multicenter prospective study

Patient experience is a key quality indicator for colonoscopy, yet standardized assessment tools are lacking in China. The Newcastle ENDOPREM scale has shown promise internationally but requires validation in China. To translate, adapt, and preliminarily evaluate the psychometric...

Tail convergence in insurance financial protection: multi-layer performance among hospitalised NCD patients in Southwest China

Introduction China’s multi-layer health insurance system provides financial protection through basic insurance (Urban Employee Basic Medical Insurance [UEBMI] and Urban-Rural Resident Basic Medical Insurance [URRBMI]), catastrophic supplemental coverage, and medical assistance. U...

TREM2 regulates continual efferocytosis of apoptotic neurons by monocyte-derived macrophages via AKT-PFKFB2-mediated glycolytic reprogramming after acute ischemic stroke

Efficient clearance of apoptotic neurons is crucial for mitigating secondary injury after acute ischemic stroke (AIS). Although monocyte-derived macrophages (MDMs) rapidly infiltrate the ischemic brain and upregulate triggering receptor expressed on myeloid cells 2 (TREM2) expres...

Squamous papilloma of the external ear in Southwest China: A large case series highlighting predominant HPV subtypes, pathologic features, and unique epidemiologic factors.

Squamous papilloma (SP) of the external ear is a rare benign neoplasm, with limited research on its associated human papillomavirus (HPV) infections and pathologic features. This study aims to provide a comprehensive analysis of the largest case series of external ear SP from Sou...