Second People's Hospital of NanTong

Predicting insulin resistance in non-diabetics

This cross-sectional study aimed to compare obesity indicators for predicting insulin resistance using machine learning. Data were obtained from NHANES 2015 to 2018, focusing on a nondiabetic adult population. Insulin resistance was defined as HOMA-IR ≥ 75th percentile of the tra...

Molecular subclassification of MGMT-unmethylated high-grade glioma identifies divergent tumor states and therapeutic vulnerabilities

MGMT-unmethylated high-grade glioma (HGG) is associated with poor response to temozolomide and limited therapeutic options. However, substantial molecular heterogeneity exists within this clinically defined subgroup and remains insufficiently characterized. Transcriptomic and cli...

PRP‐Integrated Conductive Hydrogels With Dynamic Crosslinking for Accelerated Wound Healing and Physiological Monitoring

ABSTRACT The capability to simultaneously promote wound healing and enable real‐time monitoring is critical for effective wound management, especially in dynamic and infection‐prone regions such as joints, yet unmet needs remain in clinical practice. Herein, we present a multifun...

Association between pericoronary CT fat attenuation index and coronary artery spasm

Fat attenuation index (FAI) is currently used in research on coronary atherosclerotic heart disease, but there are no reports on FAI applications in coronary artery spasm (CAS). In this study, we explored the association between pericoronary FAI and CAS. Patients who had chest pa...

Development of an explainable machine learning model for predicting six-month consciousness recovery in patients with prolonged disorders of consciousness

With advances in emergency care systems, the number of patients with prolonged disorders of consciousness (pDoC) has markedly increased. To optimize the allocation of healthcare resources and mitigate risks, the early and accurate identification of recovery potential in pDoC is e...

Transcriptomic profiling of inner ear hair cell spontaneous regeneration reveals the key role of dlx5a

Sensory hair cells (HCs) are susceptible to damage, typically causing permanent hearing and balance deficits in mammals due to limited regeneration. Understanding spontaneous regeneration in non-mammalian models offers key insights for restoring sensory function. Here, we establi...