Second Hospital of Tianjin Medical University

Distal-first versus proximal-first laparoscopic nephroureterectomy for non-muscle-invasive upper tract urothelial carcinoma: a retrospective cohort study

Abstract Background and objective The optimal sequence of ureteral and vascular control during laparoscopic nephroureterectomy (LNU) for non-muscle-invasive (≤ pT1) upper tract urothelial carcinoma (UTUC) remains controversial. We compared distal-first (initial ureteral ligation)...

Gut microbiota‑driven indole‑3‑propionic acid protects against sepsis‑associated encephalopathy via inhibiting BNIP3L ubiquitination and restoring BNIP3L‑dependent mitophagy as a potential molecular mechanism

Sepsis-associated encephalopathy (SAE) is a severe refractory neurological complication occurring in up to 70% sepsis patients with no targeted therapies. Gut microbiota-derived indole-3-propionic acid (IPA), a tryptophan metabolite, exerts neuroprotective effects, but its therap...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

Spliceosome gene mutations synergize with anthracyclines to amplify atrial fibrillation risk in hematologic malignancies: a multicenter cohort study with discovery and validation

Abstract Background Atrial fibrillation (AF) is a life‑threatening complication in patients with hematologic malignancies, yet personalized risk stratification remains challenging. Spliceosome gene mutations are key drivers of these malignancies, but their specific role in AF pat...

NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer

Abstract Loss of primary cilia is common in cancer, but its relevance to molecular subtypes of muscle-invasive bladder cancer (MIBC) is unclear. Here, we combined transcriptomic and co-expression analyses with experiments in bladder cancer cell lines, human tumor specimens, and x...

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Local flow patterns determine the uneven distribution of atherosclerotic lesions, yet the underlying mechanism remains poorly defined. We previously reported that protein tyrosine phosphatase nonreceptor type 14 (PTPN14) is implicated in atherosclerosis. Its role in flow-dependen...

Fine-tuning an ECG foundation model to predict coronary CT angiography outcomes

<title>Abstract</title> Coronary artery disease (CAD) remains a major global health burden. Accurate identification of the culprit vessel and assessment of stenosis severity are essential for guiding individualized therapy. Although coronary CT angiography (CCTA) is the first-lin...

Ambient nitrogen dioxide and composition-specific risk of urolithiasis: a multicenter time-stratified case-crossover study

Background: Emerging evidence suggests that ambient air pollution and meteorological variation may trigger urolithiasis, but stone-composition–specific and lagged associations are poorly characterized.Methods: We conducted a multicenter, time-stratified case-crossover study in Gu...

Validation of the “purfling sign” for differentiating primary central nervous system lymphoma from high-grade glioma: a retrospective multicenter cohort study

Abstract Background The study aimed to evaluate whether the imaging marker “purfling sign” can reliably distinguish primary central nervous system lymphoma (PCNSL) from high-grade glioma and systematically assess its diagnostic performance, differential utility and clinical value...

Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis

Abstract Background Ambient temperature is an important environmental determinant of cardiovascular health. Although cold exposure has been associated with acute myocardial infarction (MI), evidence on delayed effects and subtype-specific differences remains limited in northern C...

Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis

Nephrectomy is standard for kidney tumors and living kidney donation, but postoperative chronic kidney disease (CKD) is a critical determinant of long-term outcomes. Risk factors for incident CKD after unilateral nephrectomy remain incompletely synthesized. PubMed, Embase, Web of...