Second Affiliated Hospital of Zhengzhou University

Serial versus updated MELD for conditional 28-day mortality in critically ill patients with cirrhosis and sepsis: a landmark cohort study

Whether an admission-window Model for End-stage Liver Disease (MELD) score adds predictive information once an updated score is known remains uncertain in critically ill patients with cirrhosis and sepsis. We studied adults in MIMIC-IV v3.1 who were alive and hospitalized 72 h af...

A chemoresistance-associated proliferation gene signature identified by single-cell and machine learning analysis predicts prognosis in high-grade serous ovarian carcinoma

Background High-grade serous ovarian carcinoma (HGSOC) features extensive intratumoral heterogeneity, frequent chemoresistance and poor prognosis. Tumor proliferation kinetics reflected by tumor doubling time (TDT) are linked to therapeutic response, yet molecular drivers of chem...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

EMMPRIN-mediated metabolism of monocytes promotes disease progression in a mouse model of multiple sclerosis

Monocytes and monocyte-derived macrophages are increasingly recognized as key contributors to the initiation and progression of inflammatory conditions, in part through metabolic reprogramming that drives pathogenic inflammatory phenotypes. However, the upstream mechanisms that c...