Second Affiliated Hospital of Xinjiang Medical University

Serum basic amino acids, prolactin, and insomnia severity in perimenopausal individuals: a cross-sectional sub-study

Insomnia symptoms are common during the menopausal transition, but estrogen-centered explanations do not fully account for inter-individual variation. We examined whether serum prolactin was associated with insomnia severity and whether circulating basic amino acids modified this...

WEM-Mamba: a Wavelet-Enhanced MedMamba framework for rotator cuff tear classification in X-ray images

Rotator cuff tear is a common cause of shoulder pain and functional impairment, and its accurate identification is of great significance for clinical treatment decisions. Magnetic Resonance Imaging (MRI) is generally regarded as the important imaging modality for evaluating soft...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

Single-Cell Transcriptomic Profiling of the O -Methyltransferase Characteristics of Flavonoid Biosynthesis in Ziziphus jujuba var. spinosa Fruit

Abstract Sour jujube (Ziziphus jujuba var. spinosa) is a valuable medicinal and edible fruit owing to its health-promoting properties. Methoxylated flavonoids enhance their value by improving stability and bioavailability. However, the cellular basis of their biosynthesis remains...

Establishment Reference Intervals Using the Kosmic Algorithm for Hemoglobin Levels and Platelet, Red Blood Cell, and White Blood Cell Counts

INTRODUCTION: Reference intervals (RIs) for complete blood count (CBC) are crucial for assessment of overall health status and effective diagnosis of diseases. However, the RI data for CBC currently used in clinical practice in China are mainly derived from the Han Chinese popula...

Predictive model for mild cognitive impairment risk in community-dwelling older adults with depressive symptoms based on explainable machine learning: a cross-sectional study

Abstract Background: Mild cognitive impairment (MCI) represents a high-risk prodromal stage of Alzheimer’s disease, and its prevalence and conversion risk are higher among community-dwelling older adults presenting with depressive symptoms. Currently, there is a lack of interpret...

Qufeng Zhijing Capsule attenuates airway inflammation in experimental asthma and is associated with c-Myc/YTHDF1/TRPV1-related signaling

Background Qufeng Zhijing Capsule (QFZJ) is a traditional Chinese medicine formulation used for asthma-related respiratory symptoms, but its effects on airway epithelial inflammation and the underlying molecular mechanisms remain unclear. Methods OVA-induced asthmatic rats receiv...