Second Affiliated Hospital of Xi'an Jiaotong University

Single-cell RNA sequencing reveals chondrocyte heterogeneity and fibrocartilage transition in osteonecrosis of the femoral head

Cartilage degeneration in osteonecrosis of the femoral head (ONFH) is closely associated with chondrocyte heterogeneity. Single-cell RNA sequencing was performed on 50,851 chondrocytes from 10 ONFH patients and 10 controls. The findings were further validated using an in vitro ch...

Anti-nephrolithiatic Activity of Acacetin in Ethylene Glycol-Induced Nephrolithiasis in Rats

Nephrolithiasis, commonly known as kidney stones, is a prevalent urological disorder characterized by the accumulation of crystalline deposits in the kidneys. This condition is linked to considerable morbidity owing to the accompanying colicky pain, the necessity for surgical int...

Accuracy assessment of Chinese large language models in psoriasis management: a multicenter expert evaluation study

Psoriasis patients in China face severe barriers to disease knowledge acquisition and limited access to medical resources, creating an urgent demand for reliable, evidence-based patient education tools. This multicenter expert evaluation study aimed to systematically assess the q...

Defensive adoption and the intermediate coding threshold in generative AI usage among medical postgraduates: a cross-sectional mixed-methods study

The integration of generative artificial intelligence (GenAI) in medical research presents both methodological opportunities and pedagogical challenges. While traditional technology acceptance models characterize anxiety as a barrier to adoption, high-pressure academic environmen...

A tumor microenvironment acid-responsive therapy combining fenton chemistry and chemotherapy via TNF pathway for synergistic and safe lung cancer treatment

Lung cancer is one of the most common malignant tumors, but traditional treatments, particularly chemotherapy, often face significant challenges, including drug resistance and high systemic toxicity. In this study, we developed a novel acid responsive nanoparticle, La₂O₃@PDA/PTX,...

Controlled hypotension therapy with isosorbide dinitrate for postoperative bleeding of transurethral resection of the prostate

Introduction: Postoperative bleeding is a well-known complication of transurethral resection of the prostate (TURP). This study aims to evaluate the efficacy and safety of controlled hypotension using isosorbide dinitrate (ISDN) as a treatment for refractory postoperative bleedin...

Development and external validation of an inflammation-based nomogram for predicting short-term mortality in cirrhotic patients with esophagogastric variceal bleeding

Abstract Background Early and accurate risk stratification is critical for managing cirrhotic patients with esophagogastric variceal bleeding (EGVB). Inflammatory biomarkers derived from complete blood counts may offer prognostic value, yet their comparative performance remains u...

Glucagon-like peptide 1 receptor agonists in cardiovascular-kidney-metabolic syndrome: a review

With the rising global prevalence of obesity and type 2 diabetes, metabolic disorders have become major drivers of cardiovascular morbidity and mortality worldwide. Cardiovascular-kidney-metabolic (CKM) syndrome encompasses obesity, type 2 diabetes mellitus (T2DM), chronic kidney...

Comparison of ultrasound-guided two-point block of the rhomboid intercostal vs. thoracic paravertebral for postoperative analgesia in patients undergoing three-port thoracoscopic surgery: a prospective, randomized, non-inferiority study

Background The anesthetic characteristics of ultrasound-guided two-point rhomboid intercostal block (RIB) have not been fully established. This study compared the analgesic efficacy of ultrasound-guided two-point RIB with that of two-point thoracic paravertebral block (TPVB) for...