Second Affiliated Hospital of Xi'an Jiaotong University

Associations of anthropometric indices with all-cause and cause-specific mortality among US adults with a self-reported history of cancer: a population-based cohort study

Abstract Background Obesity is a well-established risk factor for cancer incidence and mortality. Body mass index (BMI) does not adequately characterize body shape or fat distribution. Whether a body shape index (ABSI) and body roundness index (BRI) are associated with mortality...

Pulse intensity threshold regulates electroporation Nanodelivery: biological mechanisms and signaling Cascade

Abstract Background Reversible electroporation enhances nanoparticle internalization, but the coordinated regulation of delivery efficiency and cellular responses by pulse parameters remains unclear. This study aims to elucidate the regulatory logic underlying gradient electric p...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Integrative pan-cancer profiling identifies BRIX1 as a candidate prognostic biomarker and potential therapeutic target in liver hepatocellular carcinoma

BRIX1 belongs to the Brix domain-containing protein family and participates in ribosomal assembly and in cell growth regulation. Nevertheless, a systematic pan-cancer assessment of BRIX1 expression and its clinical implications in liver hepatocellular carcinoma (LIHC) remains lac...

CTCF-FXN regulatory axis plays critical roles in clinical assessments and disease progression of primary open-angle glaucoma

Primary open-angle glaucoma (POAG) is an irreversible ophthalmic disease that is the leading cause of blindness. Oxidative stress (OS) is considered an important contributor to POAG pathogenesis. However, its mechanism of action in POAG remains vague. FXN was identified as a cand...

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

ABSTRACT Iron homeostasis plays a critical role in the pathogenesis and therapeutic management of hepatocellular carcinoma (HCC). Magnetoreceptor (MagR), also known as iron‐sulfur cluster assembly protein 1 (ISCA1), is a conserved protein maintaining iron homeostasis, plays an un...

IRF1-mediated thioredoxin (TXN) protects multiple myeloma cells from ferroptosis through remodeling of PUFA-containing phospholipids

Abstract Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled plasma cell proliferation and frequent therapeutic relapse. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic vu...

PPARα Activation Attenuates Right Ventricular Hypertrophy by Regulating Myocardial Glucose and Lipid Metabolism in High-Altitude Pulmonary Hypertension In Vivo and In Vitro

Zhang, Xiaoying, Jiajia Wu, Yuchan Zhang, Yuquan Xie, Qi Si, Shadi Li, and Yiwei Han. PPARα activation attenuates right ventricular hypertrophy by regulating myocardial glucose and lipid metabolism in high-altitude pulmonary hypertension in vivo and in vitro . High Alt Med Biol....

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

Triglyceride glucose-body mass index (TyG-BMI): mechanisms, multi-organ predictive value, and artificial intelligence-assisted risk stratification in type 2 diabetes mellitus

Abstract Type 2 diabetes mellitus (T2DM) has evolved into a global public health crisis characterized by high prevalence, chronic progression, and multisystem complications, including cardiovascular, renal, hepatic, and bone metabolic disorders. Insulin resistance (IR) serves as...

Factors associated with frailty and six-month readmission in older patients with atrial fibrillation: a single-center retrospective cohort study

To examine clinical factors associated with frailty and evaluate short-term outcomes among older hospitalized patients with atrial fibrillation (AF). This single-center retrospective cohort study included 198 patients aged ≥ 60 years with documented AF who were hospitalized betwe...

Apolipoprotein A-IV deficiency rewires renal fibroblast states and intercellular communication during early obesity-associated chronic kidney disease

Abstract Aims Obesity is a major risk factor for the development and progression of chronic kidney disease (CKD). Apolipoprotein A4 (Apoa4), a key regulator of lipid and glucose metabolism, also possesses immunomodulatory properties. This study aimed to investigate the role of Ap...

Characterizations of the multi-kingdom gut microbiota in elderly individuals with end-stage renal disease

End-stage renal disease (ESRD) is common in older adults and has been linked to gut dysbiosis, yet multi-kingdom alterations and cross-kingdom interactions in elderly patients remain incompletely defined. We characterized the gut bacteriome, mycobiome, and virome in elderly indiv...

Medial Temporal Atrophy and Posterior Cingulate Structural Covariance in Mild Cognitive Impairment

BACKGROUND: Mild cognitive impairment (MCI) is associated with structural abnormalities in regions vulnerable to Alzheimer's disease, but the relative contributions of medial temporal, posterior midline, and association cortices remain unclear. We compared regional gray matter vo...

Memristors Empowering Next‐Generation Human‐Computer Interaction

ABSTRACT With the continuous advancement of artificial intelligence, human‐computer interaction (HCI) is evolving toward intelligent perception, collaborative decision‐making, and natural integration. However, the physical separation of memory and computing units in traditional v...

Time to benefit of perioperative immunotherapy among patients with resectable non-small-cell lung cancer

Abstract Background The optimal duration of perioperative immunotherapy for resectable non–small-cell lung cancer (NSCLC) remains undefined, and conventional efficacy measures provide limited insight into the temporal pattern of benefit emergence, for which time-to-benefit (TTB)...

Hip muscle radiodensity measured using computed tomography is associated with femoral density and proximal femoral fracture status in an elderly population: a retrospective case–control study

Abstract Background Preventing proximal femoral fractures in older adults is of paramount importance. In clinical practice, bone mineral density measured by dual-energy X-ray absorptiometry is the reference standard for assessing skeletal fragility, whereas muscle is rarely quant...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...