Second Affiliated Hospital of Shantou University Medical College

The DTI-ALPS index covaries with regional thalamic tissue susceptibility rather than clinical severity in Parkinson’s disease: a cross-sectional multimodal MRI study

Abstract Background The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is widely used as a non-invasive proxy for glymphatic function, but its biological specificity is increasingly questioned. Its region of interest lies in white matter sharing tha...

In vitro and in vivo evaluation of YIGSR-modified liposomes co-loaded with doxorubicin and 5F

Targeted liposomes represent an excellent drug delivery system for enhancing therapeutic effects. In this study, a novel YIGSR-modified liposomal formulation co-encapsulating two antitumor drugs, doxorubicin (DOX) and ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), was develo...

Nanomedicines for resistant tumours in the central nervous system: novel materials and mechanisms of action

Central nervous system (CNS) tumours have a dismal prognosis, primarily due to the systemic therapeutic resistance that tumours develop through complex multidimensional networks. Factors related to therapeutic efficacy include: (i) natural physical barriers (e.g., the blood–brain...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...