Second Affiliated Hospital of Shantou University Medical College

Task-Evoked Metabolic Balance and Intrinsic Network Organization Relate to Processing Speed

Abstract Processing speed is a core component of cognition that declines with aging and is impaired across neurological and psychiatric disorders. We combined functional proton magnetic resonance spectroscopy at 7 T with resting-state functional MRI to examine neurochemical and f...

Validated RP-HPLC method for simultaneous determination of doxorubicin and 5F: application in nanoliposome formulation development and pharmacokinetic studies

Objective The study aims to develop a reversed-phase high-performance liquidchromatography (RP-HPLC) method for the simultaneous determination of two antitumor drugs, doxorubicin (DOX) and ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), in KM mice plasma following intravenous...

Deep Learning-Enhanced Lateral-Flow Microarray Biosensor for Multiplexed Inflammatory Biomarker Analysis

Abstract Beyond simply functional integration, achieving synergistic enhancements in multiplex detection, quantitative robustness, and intelligent analysis remains a key challenge for next-generation biosensing platforms in precision diagnostics. Lateral flow biosensors are attra...

Comparison of machine learning models for predicting in-hospital Glasgow Coma Scale improvement after surgery in patients with severe traumatic brain injury

Traumatic brain injury (TBI) is a major cause of disability and death worldwide. In patients with severe TBI, early identification of those less likely to demonstrate neurological improvement during hospitalization may assist postoperative monitoring and risk stratification. This...

Self-assembled products from natural active compounds: mechanisms and applications in cancer therapy

Natural active compounds (NACs) possess diverse anticancer activities but are often limited by poor aqueous solubility, low bioavailability, insufficient tumor selectivity, and inadequate in vivo stability. Self-assembled products from natural active compounds (SAPNACs) provide a...

Influencing factors and the pathway analysis of demoralization among stroke patients: a cross-sectional study

Demoralization was found to seriously harm patients‘ disease outcomes and quality of life, and could even lead to suicidal ideation and shorten life expectancy. Understanding the level of demoralization in stroke patients and exploring its mechanism wasconsidered not only conduci...

The DTI-ALPS index covaries with regional thalamic tissue susceptibility rather than clinical severity in Parkinson’s disease: a cross-sectional multimodal MRI study

Abstract Background The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is widely used as a non-invasive proxy for glymphatic function, but its biological specificity is increasingly questioned. Its region of interest lies in white matter sharing tha...

In vitro and in vivo evaluation of YIGSR-modified liposomes co-loaded with doxorubicin and 5F

Targeted liposomes represent an excellent drug delivery system for enhancing therapeutic effects. In this study, a novel YIGSR-modified liposomal formulation co-encapsulating two antitumor drugs, doxorubicin (DOX) and ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), was develo...

Nanomedicines for resistant tumours in the central nervous system: novel materials and mechanisms of action

Central nervous system (CNS) tumours have a dismal prognosis, primarily due to the systemic therapeutic resistance that tumours develop through complex multidimensional networks. Factors related to therapeutic efficacy include: (i) natural physical barriers (e.g., the blood–brain...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...