Second Affiliated Hospital of Kunming Medical College

Health inequalities in the global reproductive-age population: GBD 2021 trends and female-male differences, 1990–2021

Socioeconomic health inequality among reproductive-age populations remains insufficiently characterized globally. Using GBD 2021 data for individuals aged 15–49 years in 204 countries and territories, we assessed disability-adjusted life year (DALY) rates and quantified absolute...

Factors affecting the decline of intrinsic capacity of older adults in Chinese communities: a systematic review and meta-analysis

With the rapid aging of the global population, maintaining the intrinsic capacity of older adults has become a critical public health priority. However, the pooled prevalence of intrinsic capacity decline and its key determinants remain unclear. This study aims to assess the rate...

Exosomal lncRNAs in Cerebrovascular Diseases: Biomarkers, Pathological Mechanisms, and Therapeutic Potential

Background: Cerebrovascular diseases have complex pathogenesis and pose a serious threat to human health; thus, novel diagnostic and therapeutic strategies are needed. Small extracellular vesicles (sEVs), commonly referred to as exosomes, are 30–150 nm lipid-bilayer vesicles that...

Exploration and practice of a DeepSeek‑enhanced, scenario‑based teaching model integrated with a multidisciplinary team approach in gastroenterology residency training

The first year of standardised residency training is a critical transition from medical student to clinical practitioner, during which trainees struggle to integrate theoretical knowledge with clinical competencies. Traditional teaching often lacks active learning and authentic c...

Raw pyrite tailings as fine aggregate in mortar: performance and potential for architectural surface design

The accumulation of pyrite tailings (PT) poses severe environmental threats, yet its potential as a secondary resource for the construction sector remains underexplored. This study presents a preliminary investigation of raw PT as a partial substitute for fine aggregate in mortar...

Glymphatic-meningeal lymphatic dysfunction drives remote organ injury after aneurysmal subarachnoid hemorrhage: a unified neuroimmune framework and time-stratified therapeutic roadmap

Aneurysmal subarachnoid hemorrhage (aSAH) confers substantial mortality and morbidity driven not only by primary brain injury but also by systemic remote organ complications across the pulmonary, cardiac, renal and gastrointestinal systems. Despite growing recognition of neuroimm...