Second Affiliated Hospital of Jilin University

Artificial intelligence empowering the diagnosis and treatment of rotator cuff tears

Background: Artificial intelligence (AI) is being developed for image acquisition, quantitative tissue assessment, diagnosis, and clinical prediction in rotator cuff tears. The breadth of this literature and its methodological limitations have not been integrated across the compl...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Raman Self‐Tracking Copper Metal‐Organic Framework‐Based Nanoplatform for Cuproptosis Cancer Therapy

ABSTRACT Cuproptosis represents a promising strategy for cancer therapy, yet its clinical translation is hampered by unexpected deactivation and off‐target toxicity of copper ions during their delivery to tumors. We developed a copper metal‐organic framework‐based nanoplatform (C...

An imputation method for single‐cell RNA sequencing data based on a parallel gated recurrent unit neural network

Abstract Single‐cell RNA sequencing (scRNA‐seq) generates high‐dimensional transcriptomic data but is severely affected by dropout events, which obscure true gene–gene relationships. These missing values introduce bias into downstream analyses, complicate data processing, and red...

Cationic Amphiphilic Polypeptides With Immunogenic Cell Death Inducing Activity for Inhibition of Metastatic Bone Cancer

Immunogenic cell death (ICD)-mediated activation of antitumor immunity is being explored as a therapeutic approach for cancers with bone metastasis. In this study, several cationic amphiphilic polypeptides were obtained to investigate their architecture-dependent cytotoxicity and...

A pile foundation reconstruction prosthesis for severe acetabular bone defects

Aims: Severe acetabular bone defects generally refer to Paprosky III defects and pelvic discontinuity. Reconstruction surgery for these is complex, and requires innovative strategies to address implant failure and reconstruct the acetabulum. Traditional reconstruction methods rel...

Sex-specific proteomic risk scores reveal distinct cardiovascular risk profiles and improve prediction of major adverse cardiovascular events in hypertension

Abstract Background Individuals with hypertension face a substantial residual risk of major adverse cardiovascular events (MACE), yet current clinical risk models often fail to capture the complex pathophysiological heterogeneity and sex differences within this population. This s...

Visualized self-propelled nanorobots overcome tumor barriers for boosted photothermal-nanocatalytic synergistic therapy against triple-negative breast cancer

Conventional nanozyme-based therapeutics for triple-negative breast cancer (TNBC) are severely hindered by insufficient tumor penetration and lysosomal degradation-induced enzyme inactivation, crippling therapeutic efficacy. Herein, we rationally construct visualized dual-propell...

KneeFusionNet Enables Accurate and Efficient Comprehensive Detection of Knee Ligament Injuries on Magnetic Resonance Imaging: A Multicenter Validation Study

Purpose To develop and externally validate KneeFusionNet, a multimodal deep learning model for detecting anterior cruciate ligament (ACL), posterior cruciate ligament (PCL), medial collateral ligament (MCL), and lateral collateral ligament (LCL) injuries on knee magnetic resonanc...

Intelligent diagnosis of vocal cord lesions via multimodal deep learning: integrating laryngoscopy, voice, and biomarkers

Abstract Background Accurate pre‑operative diagnosis of vocal cord lesions remains challenging. We developed a multimodal deep learning model that integrates laryngoscopic images, voice recordings, and biochemical markers to improve diagnostic accuracy. Methods In this retrospect...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...

Sitting Time and Physical Activity Correlate With Asthma Exacerbations in Adults: A Cross‐Sectional Study From the Australasian Severe Asthma Network

Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.

Causal effects of diabetes and alcohol intake on Dupuytren’s disease: a two-sample Mendelian randomization study in UK Biobank and FinnGen

Background: Dupuytren's disease (DD) is associated with metabolic and lifestyle traits. However, these associations remain uncertain because exposures frequently cluster, and conventional studies are vulnerable to residual confounding and reverse causation. Methods: A two-sample...

Research progress on the effect of sericin on bone regeneration

Sericin is a waste material from the silk production process, researchers its found to have good biological activity and is widely used in tissue engineering. The aim of this paper is to summarize the biological applications of sericin in the field of bone tissue engineering and...

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease...