Second Affiliated Hospital of Fujian Medical University

A Risk‐Based Prioritization Model for Advanced Colorectal Neoplasia in Thailand: Strengths and Open Questions

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

NR3C2 suppresses triple-negative breast cancer progression by regulating mitochondrial ROS homeostasis via NDUFB3

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high molecular heterogeneity and a lack of effective targeted therapies. Increasing evidence indicates that metabolic reprogramming and redox homeostasis are critical determinants of T...

C‐reactive protein–triglyceride glucose index and all‐cause mortality in postmenopausal women: A dual‐cohort study from the National Health and Nutrition Examination Survey and the China Health and Retirement Longitudinal Study

BACKGROUND: Insulin resistance and chronic inflammation each predict cardiovascular mortality, but they are usually studied separately. The C-reactive protein-triglyceride glucose index (CTI) combines both, yet its prognostic value in postmenopausal women, who experience concurre...

Development and Validation of an Interpretable Machine Learning Model for Osteoporosis Prediction Using Multimodal Musculoskeletal Ultrasound and Clinical Features

Objectives This study aimed to develop and validate an interpretable machine learning model for osteoporosis prediction based on multimodal ultrasound and clinical features. Methods Participants with suspected osteoporosis were enrolled from 2 medical centers. Clinical variables...

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

ABSTRACT Resistance to second‐generation antiandrogens poses a major therapeutic challenge in castration‐resistant prostate cancer (CRPC). While ferroptosis evasion has been implicated in treatment failure, the key molecular determinants driving this evasive process are poorly un...

Trends in incidence, prevalence, and mortality of peptic ulcer disease in Asia (1990–2023) and projections to 2040

Background: This study provides the first comprehensive assessment of the burden of peptic ulcer disease (PUD) in Asia, analyzing epidemiological trends from 1990 to 2023 with projections to 2040. Methods: Using data from the Global Burden of Disease Study 2023, we analyzed PUD m...

Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation

Background Cataract is a highly prevalent cause of visual impairment and blindness worldwide. Although genome-wide association studies (GWAS) have mapped multiple cataract risk loci, further work is required towards translating these signals and integrating multi-omics evidence f...

A retrospective study of correlation between insulin resistance surrogate indexes, inflammatory markers, and peripheral arterial disease in type 2 diabetes mellitus

Background This study aimed to investigate the correlation between six surrogate indexes of insulin resistance (IR) and six inflammatory markers with diabetic peripheral arterial disease (DPAD) in patients with type 2 diabetes mellitus (T2DM). Methods Clinical and hematological d...

Bisphenol A and Its Substitutes Bisphenol S/Bisphenol F in Combined Exposure Collectively Exacerbate Hepatotoxicity by Triggering Oxidative Stress and Inflammatory Responses via the PI3K-Akt/NF-κB Axis

Abstract Bisphenol A (BPA) and its substitutes bisphenol S (BPS) and bisphenol F (BPF) are environmental endocrine-disrupting chemicals that frequently co-occur. However, the hepatotoxic effects and underlying mechanisms of their combined exposure remain unclear. This study integ...

A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer

Abstract Background The therapeutic potential of oncolytic adenoviruses (ADVs) in colorectal cancer is constrained by a counterproductive host response: virus-triggered hyperactivation of the pro-survival AKT pathway, which fosters an immunosuppressive tumor microenvironment. Met...

Preoperative vascular status, left colic artery management, and clinically relevant anastomotic leakage after anterior resection for rectal cancer: a retrospective cohort study

Clinically relevant anastomotic leakage after rectal cancer surgery is multifactorial, and baseline vascular status may contribute to anastomotic perfusion risk. This study evaluated the associations of patient-level vascular comorbidity, preoperative CT/CTA-derived vascular stat...

Establishment of an enteral nutrition pathway for malignant esophageal obstruction using combined esophageal stenting and gastrostomy

Malnutrition is common in patients with advanced esophageal cancer and is associated with poor outcomes. While esophageal stenting can relieve dysphagia, oral intake alone is often insufficient. Percutaneous endoscopic gastrostomy (PEG) provides reliable nutritional support but d...

Association between cardiometabolic index and incident electrocardiographic abnormalities in older adults

Electrocardiographic (ECG) abnormalities are important predictors of cardiovascular events in older adults, yet their early identification remains challenging. The cardiometabolic index (CMI), which integrates central obesity and lipid metabolism, has emerged as a potential marke...

CT-based three-dimensional virtual reduction with implant templating for tibial plateau fractures involving the posterolateral region: a retrospective cohort study of early postoperative CT reduction quality

Tibial plateau fractures involving the posterolateral region remain technically challenging because of their deep location, limited surgical exposure, and surrounding anatomical constraints. This study investigated whether CT-based three-dimensional virtual reduction with implant...

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

Perioperative Imatinib Treatment Continuation Patterns and Long-Term Outcomes in Locally Advanced Gastrointestinal Stromal Tumors After Neoadjuvant Therapy: An Exploratory Two-Center Retrospective Study

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...