Second Affiliated Hospital of Chengdu University of Traditional Chinese

Shared genetic architecture underlying cataract and cardiovascular disease: insights from multi-omics analyses

Abstract Cataract and cardiovascular disease (CVD) are prevalent age-related disorders with overlapping risk factors. While epidemiological associations are established, the shared genetic mechanisms underlying their comorbidity remain largely unexplored. We performed a comprehen...

Patient-family concordance in end-of-life decision-making preferences among terminally ill older adults: a cross-sectional study

Family members frequently participate in end-of-life (EOL) decision-making for terminally ill older adults; however, family-member preferences for the patient may not align with the patient’s own preferences. Such discordance can complicate treatment planning and efforts to provi...

Modified single-port laparoscopic lateral suspension with bilateral 2-mm micropunctures for moderate-to-severe pelvic organ prolapse: a prospective single-arm feasibility study

Pelvic organ prolapse (POP) affects up to 40% of women over 50 years, with traditional surgical approaches carrying significant morbidity. We evaluated the feasibility and preliminary safety and efficacy of a modified single-port laparoscopic lateral suspension (LLS) technique us...

Comparative evaluation of dental pulp and periodontal ligament stem cell sheets for rescuing periodontal-like tissue formation in cryopreserved tooth autotransplantation

Autologous tooth transplantation (ATT) is a biologically based approach for the management of tooth loss, particularly among adolescents. However, its broader application is limited by challenges associated with tooth cryopreservation and stem cell-based strategies, and current s...

Triaptosis-related prognostic model for lung adenocarcinoma based on transcriptomic analysis and experimental validation

Abstract Background The role of triaptosis, as a novel form of regulated cell death (RCD), remains poorly understood in lung adenocarcinoma (LUAD). This study scout to identify triaptosis-related prognostic genes in LUAD and construct a prognostic model. Methods Triaptosis-relate...

A dynamically coordinated bioactive MOF-hydrogel system for ternary microenvironment reprogramming in MRSA-infected diabetic wounds

Due to a persistent inflammatory response, excessive accumulation of ROS, and MRSA infection, the repair of diabetic chronic wounds faces severe challenges. Here, an intrinsically bioactive MOF-hydrogel system (SR@P/L) was designed to accelerate wound healing by reprogramming the...