Seattle University

Emergent properties of urban landscapes shape urban eco-evolutionary dynamics

Abstract Context Urbanization transforms natural ecosystems into heterogeneous and fragmented landscapes, creating novel selective pressures that can drive eco-evolutionary dynamics. However, the specific role of urban spatial structure in shaping these dynamics remains poorly un...

Small area estimation in low- and middle-income countries with the sae4health R shiny application

Abstract Accurate subnational estimation of health indicators is critical for public health planning, particularly in low- and middle-income countries, where data and analytic tools are often limited. sae4health is an open-access Shiny application ( https://rsc.stat.washington.ed...

YouCred: An Online Tool Co-Designed with Fact-Checkers for Misinformation Discovery on YouTube

Monitoring online platforms, one of the most challenging aspects of the fact-checking process, remains predominantly manual. Crafting search queries to surface potentially dubious online content is based on guesswork, demanding significant time and effort from fact-checkers. Whil...

The Social Nature of Vaping: A Qualitative Review of Substance Use, Social Media, and Adolescent Nicotine Use

This review examines the mechanisms by which adolescents encounter and access substances through social media platforms and social facilitators of substance use, including peer influence. It synthesizes data from three qualitative studies identified in a systematic review and ana...

IL-2 mutein selectively expands thymic memory Tregs with increased transendocytosis activity in healthy participants

Tregs play an essential role in immune tolerance, and Treg-promoting therapies are in development for the treatment of many inflammatory disorders. Interleukin-2 (IL-2)-based therapies increase Treg frequency, but little is known about impacts on Treg heterogeneity and function....

Targeting tryptophan hydroxylase 1 restricts growth and suppresses plasticity in neuroendocrine prostate cancer

Advanced prostate cancer has increasingly developed a lethal neuroendocrine form, small cell/neuroendocrine prostate cancer (NEPC), as a consequence of the widespread use of highly potent androgen receptor signaling inhibitors in castration-resistant disease. The molecular mechan...

Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis

Abstract This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of...

Reading Between the Lines: A Scoping Review of Large Language Models in Conversational Data Analysis

Transformer-based large language models are becoming increasingly popular in supporting qualitative analysis, but their applications and validation are often poorly characterized. This scoping review followed PRISMA-ScR rules to understand how such models are used in the analysis...

Cross-platformization: How U.S. right-leaning media curate their posts on Twitter and Truth Social

This study examines how seven right-leaning media organizations utilize cross-platformization strategies to reach audiences across multiple platforms; in this case, Twitter and Truth Social. Focusing on both content volume and story packaging, we collect right-leaning media organ...

Early Childhood Services for Transfronterizx Families of Autistic Children: Perspectives From Community Providers

In this qualitative study, we investigated the perspectives of early childhood service (ECS) providers on the facilitators and barriers faced by transfronterizx caregivers of autistic children in the U.S.-Mexico border. We applied thematic analysis to focus groups using the socio...

Characteristics and Timing of Dual Pediatric Palliative Care and Ethics Consultations

Abstract Patients with serious illness hospitalized in the pediatric setting can receive support from Pediatric Palliative Care (PPC) and Ethics Consultation (EC). However, empirical data on dual PPC-EC involvement in pediatrics is limited. Therefore, we characterized ethical iss...

Multi-stakeholder perspectives on acceptability and delivery of buprenorphine for women who use drugs

Women who use drugs (WWUD) face substantial barriers to accessing medications for opioid use disorder (MOUD), including buprenorphine. As part of a formative evaluation to co-design a community-based intervention for MOUD delivery, we explored multi-stakeholder perspectives on th...

Determinants of scaled implementation for electronic laboratory information systems in 27 clinical laboratories in Côte d’Ivoire: a mixed-methods study applying the Consolidated Framework for Implementation Research (CFIR)

Abstract Background Electronic laboratory information systems (LIS) are critical for promoting data quality and improving laboratory performance, but sustained implementation following system deployment in resource-limited settings can be challenging. The OpenELIS project in Côte...

Distribution of device-measured 24-hour movement behaviours across the cognitive spectrum in older adults: the HUNT study

Abstract Background Key daily physical activities (e.g., standing and walking), postures (sitting and lying), and sleep constitute the 24-h day and have distinct health effects and functional implications. Traditionally studied separately, the distribution of these movement behav...

Optimization Strategies for the Design and Application of Titanium Structures in Aerospace Produced by Electron Beam Powder Bed Fusion

Material optimization of structures is critical in aerospace applications where the overall performance and lifecycle cost is highly sensitive to the vehicle weight. The added complexity enabled by powder bed fusion additive manufacturing technologies provides engineers the abili...

Performative Music Education Pathways: Bomba as a Framework for Music Teaching and Learning

For decades, music education has sought models that move beyond the confines of formal instruction. Performative Music Education (PME) offers a framework for meaningful learning experiences, grounded in philosophical perspectives from diverse fields. PME fosters musical skills, k...

Communication and coordination during mass casualty incidents: experiences of staff from a district-level university hospital in Ghana

Mass casualty incidents (MCI) are of significant public health concern. Most health facilities in developing countries often struggle to be fully prepared for MCI. MCI preparedness among other factors involves important processes like communication among staff on the emergency re...