Seattle Children's Hospital

Cryptic Presentations of Neurologic Wilson Disease With ATP7B Peptide Assessments

Objectives: To illustrate the phenotypic variability in neurologic Wilson disease (NWD) and diagnostic value of ATP7B peptide testing in resolving WD cases. Methods: We conducted a case series analysis of 3 individuals with suspected NWD. Clinical presentation, diagnostic workup...

Databases, registries, and consortia for pediatric epilepsy and functional neurosurgery: a scoping review from the AANS/CNS Pediatric Section Epilepsy and Functional Research Interest Group

OBJECTIVE The practice of pediatric epilepsy and functional neurosurgery relies on high-quality data systems to advance clinical care, evaluate outcomes, and develop evidence. Despite the importance of multicenter research in supporting these goals, no consolidated inventory exis...

Clinician Use of an Artificial Intelligence–Enabled Clinical Information Platform

Importance Despite growing interest in the use of artificial intelligence (AI) in medicine, empirical evidence on how clinicians use these tools is limited. Objective To characterize clinician use of an AI-enabled clinical information platform, the distribution of use across the...

Influenza A virus infection induces immune dysregulation in the placenta and fetus without vertical transmission in nonhuman primates

Influenza A virus (IAV) infection during pregnancy is associated with stillbirth and preterm birth. We hypothesized that maternal IAV infection disrupts placental and fetal immune networks in ways that correlate with disease severity. Pregnant pigtail macaques were inoculated wit...

Predicting Underweight Status in Infants With Cleft Lip and/or Palate in 10 US Children's Hospitals

ObjectiveTo develop and compare models predicting which infants with cleft lip and/or palate (CL/P) will be underweight at 4 months, using multicenter electronic health record data.DesignUsing data from birth to 3 months, we evaluated 63 anthropometric, clinical, healthcare-utili...

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Emergency Hold Use in Youth With Mental Health Concerns Presenting to the Emergency Department

OBJECTIVE: Emergency holds are commonly used in mental health crisis care, yet pediatric-specific data on their application and downstream consequences for emergency department (ED) care remain limited. We sought to describe sociodemographic and clinical factors associated with e...

The Childhood Liver Disease Research Network's prospective characterization of pediatric primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare biliary fibrosing disease that leads to significant morbidity and the need for liver transplantation. The Childhood Liver Disease Research Network is conducting a prospective, observational longitudinal study to define th...

The Social Nature of Vaping: A Qualitative Review of Substance Use, Social Media, and Adolescent Nicotine Use

This review examines the mechanisms by which adolescents encounter and access substances through social media platforms and social facilitators of substance use, including peer influence. It synthesizes data from three qualitative studies identified in a systematic review and ana...

Anatomy-aware, label-informed approach improves image registration for challenging datasets

Abstract Image registration-based volumetric morphometrics have emerged as a valuable method for identifying subtle morphological differences in neuroimaging and other biomedical images. However, accurate registration out-of-the-box remains challenging when overt morphological ph...

Patient‐Specific Computational Fluid Dynamics Modeling of Airway Collapse in Infants With Robin Sequence

ABSTRACT Robin Sequence (RS) is a congenital condition in which patients experience dynamic, periodic obstruction or collapse of the upper airway due to an underdeveloped jaw and a posteriorly displaced tongue. Current clinical techniques for evaluating airway obstruction do not...

Sociodemographic and Clinical Factors Associated With Nirsevimab Receipt Among Children Aged Younger Than 20 Months in the New Vaccine Surveillance Network in 2023 to 2025

OBJECTIVES: We aim to evaluate the association of sociodemographic and clinical factors with nirsevimab receipt among children with medically attended acute respiratory illness (ARI) across multiple seasons and beyond birth hospitalization. PATIENTS AND METHODS: We included nirse...