Scripps (United States)

Divergent effects of semaglutide and CRV431 Co-therapy on liver fibrosis and HCC in MASLD mouse model

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by progressive fibrosis and an increased risk of hepatocellular carcinoma (HCC). Recently, approved drug treatments for MASLD, including thyroid hormone receptor beta (THR-β) and glucagon-like pepti...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

An enantioselective covalent inhibitor of BAX confers cytoprotection in vivo

No therapies directly block apoptosis in tissue injury or the many diseases driven by cell loss. The BCL-2 family protein BAX is a central mediator of this pathway and C126 resides within a key regulatory region where physiologic or pharmacologic ligands can activate or inhibit i...

Iron-catalyzed [1+1+1] cyclopropanation by sequential coupling of an ester to two carbenes

Traditional precious metal catalysis benefits from well-characterized inner-sphere elementary steps in which a single complex binds and unites substrates at the metal center. By contrast, base metal catalysts have recently demonstrated competence in cross-coupling transformations...

Photoproximity labeling of c-Myc reveals SLK as a cancer-specific co-regulator

Transcription factors (TFs) have long been aspirational therapeutic targets for the treatment of diseases, as their dysregulation is a common mechanism for altered cell states. Despite this, many TFs implicated in disease have disordered structures and lack canonical binding pock...

Discovery of Sphaeriaurantinsas Rapid-Acting Antiplasmodialswith Dual Activity in Blood and Liver Stages

Abstract The rapid emergence of resistance in the malaria-causing protozoan Plasmodium falciparum has heightened the demand for treatments with novel modes of action. Having evolved to produce a myriad of structurally diverse natural products (NPs) as defenses against soil-dwelli...