Science Research Laboratory

B Cell Mechanisms Underlie IgG Glycan Alterations in Obesity

Abstract Insulin resistance is a major complication of obesity. In adults with obesity insulin resistance is associated with a hyposialylation of the Fc-linked glycan on IgG, and a causal link between IgG hyposialylation and glucose dysregulation has been demonstrated in obese mi...

GlycanAge dynamics and their relationship to SCORE2 risk change over six months: a secondary analysis of a randomized controlled trial

Abstract Chronological age dominates cardiovascular (CVD) risk prediction, but glycan-based measures may better reflect biological ageing. In this secondary analysis of a six-month randomized controlled trial in Slovenia, we examined whether IgG glycosylation–derived biological a...