Santobono Children's Hospital

The Broad Clinical Heterogeneity of TRNT1-Related Autoinflammatory Syndrome: A Comprehensive Review

Mutations in the tRNA Nucleotidyl Transferase 1 (TRNT1) gene have been associated with a systemic autoinflammatory disease (SAID) that presents with a wide clinical spectrum, ranging from severe and fatal forms to milder disorders. We conducted a literature review to provide a co...

Postpandemic Trends in Pediatric Respiratory Virus Hospitalizations: A Multicenter Study, 2019–2025

ABSTRACT Background The COVID‐19 pandemic profoundly altered the circulation of respiratory viruses in children, changing the epidemiology of acute lower respiratory tract infections. In the postpandemic period, respiratory pathogens showed marked temporal variability. The 2024–2...

A survey on the institutional practices of the use of isavuconazole in onco-hematological children, on behalf of the Infectious Working Group of AIEOP

Isavuconazole is a broad-spectrum antifungal agent approved for the treatment of invasive fungal infections (IFIs) in adults and, recently, in pediatric patients aged 1 year and older. Use in the pediatric setting remains limited, but available data indicate generally favorable s...

Persistent Unexplained Hydronephrosis in an Adolescent: A Multimodal Imaging Challenge

ABSTRACT Renal vein aneurysm (RVA) is an exceptionally rare vascular anomaly and an unusual cause of hydronephrosis. We report an asymptomatic 17‐year‐old male with persistent right hydronephrosis and preserved renal function. Serial ultrasonography demonstrated progressive pelvi...

Uncovering LINC02982: a T-ALL-specific lncrna linking epigenetic regulation and metabolic pathways

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric malignancy with limited molecular biomarkers to guide diagnosis and personalized therapy. Given the critical role of long non-coding RNAs in gene regulation and chromatin dynamics, we investigated whether nove...