Sanjay Gandhi Post Graduate Institute of Medical Sciences

Renal CD163+ and CD68+ Macrophage Infiltration and Urinary sCD163 Levels in IgA Nephropathy

Background IgA Nephropathy (IgAN) often affects young adults and leads to significant renal failure in many patients in India. Macrophages are linked to renal inflammation and fibrosis. We examined CD68+ and CD163+ macrophage infiltration in renal biopsies and measured urinary an...

Microglial Mitophagy in Brain Aging: A Conceptual Framework Linking Mitochondrial Resilience, Lysosomal Function, and Inflammaging

Brain aging is characterized by heterogeneous microglial states and altered mitochondrial, metabolic, and lysosomal homeostasis. Mitophagy is central to mitochondrial quality control, but its contribution to age-associated microglial dysfunction remains incompletely understood. T...

Clinicopathological Correlation of Core-Needle Biopsy in Thyroid Nodule Assessment: Insights from a Tertiary Care Center

Abstract Background: Fine-needle aspiration cytology (FNAC) is the mainstay for thyroid nodule assessment, boasting excellent specificity and cost-effectiveness. However, its diagnostic limitations often yield nondiagnostic or indeterminate results, especially in complex thyroid...

Utilizing Inhibitor Screening Assay Results to Predict Bethesda Titers in Patients With Hemophilia A: Cost‐Effective Strategy in Resource‐Constrained Setting

ABSTRACT Background The classical or modified Nijmegen–Bethesda assay measures FVIII inhibitor titers and requires testing residual FVIII levels at multiple serial dilutions, making it prohibitively expensive in resource‐constrained settings. The study aimed to develop a cost‐eff...

Primary Signet Ring Cell Adenocarcinoma of the Appendix Masquerading as Acute Appendicitis: A Diagnostic Pitfall.

Background & Objective: Primary signet ring cell adenocarcinoma (PSRCA) of the appendix is a rare and aggressive malignancy accounting for approximately 4% of all appendiceal neoplasms. These tumors often present at an advanced stage with nonspecific clinical and radiological fin...

miR-451a is a differentially expressed blood-based microRNA in newly diagnosed CML identified by high-throughput profiling

Abstract Background microRNAs (miRNAs) are emerging as promising biomarkers in hematological malignancies due to their stability in blood. This study aimed to investigate the differential expression of miRNAs in chronic myeloid leukemia (CML) and evaluate the potential of miR-451...

Butterfly gliomas of the corpus callosum: A systematic review of the literature

Objectives: Although rare, butterfly gliomas are notorious for their inferior clinical outcomes. The objective of the present study was to systematically review the available literature regarding the optimal management protocols and prognosis of butterfly glioma based on the avai...

Parathyroid Carcinoma Revisited: Clinical and Pathological Insights From Two Decades of Experience

BACKGROUND: Parathyroid carcinoma is a rare endocrine malignancy (< 1% of primary hyperparathyroidism and 0.005% of all cancers) that often mimics a benign adenoma, leading to diagnosis only after surgery, unless invasion or metastasis is present. OBJECTIVE: To identify distingui...