Sanford Health

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Tramadol is frequently co-prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid-sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of...

A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson’s disease

<title>Abstract</title> Cognitive impairment is one of the most functionally debilitating non-motor symptoms in Parkinson's disease (PD). Yet, current diagnostic and clinical practices rely heavily on subjective assessments and burdensome behavioral testing, which lack the tempor...

Prompt Engineering of Large Language Models for Medication Dose Calculation

This study aims to design and validate a large language model (LLM) framework for systematic extraction of medication dosing across multiple therapeutic classes using electronic health record (EHR) data. Manual dose annotations were completed for 4295 medications across nine ther...