San Raffaele University of Rome

School‐Based Mindfulness Interventions in Primary Education: A Systematic Review

ABSTRACT Mindfulness has been increasingly implemented in educational settings as a strategy to support children's cognitive, emotional, and behavioral development. This PRISMA‐guided systematic review synthesized empirical evidence published between January 2020 and January 2026...

Speed-Accuracy Dissociation in Fencing: Performance Fatigability Without a Detectable Decline in Touch Accuracy: An Exploratory Study

Background: It remains unclear whether physiological load affects fencing accuracy to the same extent as movement speed and whether a shortened protocol can reproduce the outcomes of a full repeated-sprint protocol. Methods: Ten fencers (foil/épée; 7 men, 3 women; 16–30 years) co...

Preliminary evidence of long‐term safety and effectiveness of anti‐ CGRP drugs for migraine prevention in people with comorbid epilepsy: A 52‐week follow‐up retrospective study

Abstract Migraine and epilepsy frequently coexist, but evidence on the safety of calcitonin gene‐related peptide (CGRP)‐targeting therapies in people with epilepsy is lacking. We evaluated long‐term migraine and epilepsy outcomes in a real‐world multicenter retrospective cohort o...

The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence

Introduction: Berry-derived and berry-based interventions have gained increasing attention for their potential health benefits. Berries are rich in diverse bioactive compounds, including polyphenols and anthocyanins, which are associated with a broad range of biological activitie...

Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study

What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substa...

High-fat diet promotes T cell–mediated synaptic dysfunction in multiple sclerosis

Early glutamatergic synaptopathy contributes to disease progression in multiple sclerosis (MS), leading to excitotoxic synaptic damage. Although high-fat diet (HFD)–associated peripheral inflammation has been linked to central nervous system dysfunction, how metabolic and immune...

RCC-AID: Renal Cell Carcinoma AI Dataset for Medical Imaging Research

Contrast-enhanced computed tomography (CT) is central to the diagnosis, staging, and follow-up of patients with renal cell carcinoma (RCC). As artificial intelligence research into computer-aided solutions continues to grow, the need for curated and annotated datasets becomes inc...

Influence of socio-economic inequalities and healthcare organisation on HPV vaccination coverage in both sexes in the Campania region: A population-based study between 2006 and 2023

Human papillomavirus (HPV) and hepatitis B vaccinations are the only immunisation programmes that directly prevent cancer. Despite the expansion of universal, gender-neutral HPV programmes, a free and actively offered vaccination does not ensure achievement of coverage targets. W...

HIPK2 loss promotes TDP-43 cytoplasmic mis-localization through MAPK-pathway and is associated with TDP-43 proteinopathy in vivo

Abstract Homeodomain Interacting Protein Kinase 2 (HIPK2) is a stress sensor kinase that has emerged as a key regulator of neuronal homeostasis and survival. In this study, we investigated the role of HIPK2 in neurodegeneration using both in vivo and in vitro models. We show that...

Antidepressants and breast cancer risk: a meta-analysis of exposure windows and cumulative use in nearly two million women

Abstract Background The use of antidepressants is steadily increasing worldwide. This trend has a significant impact on public health and socioeconomic conditions. Although studies have looked for a possible link between antidepressants and breast cancer risk, findings remain unp...

Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges

Cardiometabolic disorders arise from interconnected metabolic, inflammatory, oxidative, mitochondrial, and vascular abnormalities. Lichens produce structurally diverse secondary metabolites, including depsides, depsidones, dibenzofurans, anthraquinones, and other phenolic compoun...

Acute Limb Ischemia During Pregnancy: A Case Report and Narrative Review of the Literature

Background: Pregnancy is a well-recognized hypercoagulable state that increases the risk of thrombotic complications, most commonly venous thromboembolism. In contrast, arterial thrombosis, including acute limb ischemia (ALI), is exceedingly rare but potentially catastrophic, and...

Nutrition, Sedentary Behaviour and Physical Activity in Undergraduate Students: A Scoping Review with PRISMA-ScR Checklist

Background/Objectives: University students are particularly vulnerable to unhealthy lifestyle behaviours, including poor dietary habits, insufficient physical activity, and prolonged sedentary time. While these three behaviours have each been extensively studied individually, the...

A bottom-up perspective on multicenter bonding in discrete molecular systems

The understanding of the properties of advanced materials requires a deep knowledge of chemical bonding beyond the classical chemical bonding picture of covalent, ionic, and metallic bonds. For this purpose, we need to include multicenter bonds into the equation. Here, we approac...

From prompting to professional judgment: Generative AI, metalinguistic competence, and human-centered continuous improvement in advertising agencies

Purpose This study examines how generative artificial intelligence reshapes creative work in advertising agencies and considers its implications for professional capability development and continuous improvement. Attention centers on everyday routines, redistribution of expertise...

Fast Sine-Transform Preconditioning for Global-in-Time Fractional Diffusion

Time-fractional diffusion equations describe subdiffusive transport in heterogeneous media, but their numerical treatment is complicated by the nonlocal Caputo derivative and by the weak singularity that the solution develops at the initial time. We study a global-in-time discret...

When Green Behavior Meets Its Limits: A Competitive Mediation Model of Employee Green Behavior and Organizational Identity in Public Organizations

ABSTRACT This study examines the interplay between green employee behavior (GEB), climate change proactive perception (CCPP), and green organizational identity (GOI) in Italian public organizations. Challenging the dominant perception‐first paradigm, we propose and test a model c...

Evidence for non-mucinous pulmonary lesions with adenocarcinoma in situ morphology exceeding the current 3 cm WHO threshold

CONTEXT: The World Health Organization (WHO) recognizes adenocarcinoma in situ (AIS) of the lung for tumors up to 3 cm in size. Larger tumors with a lepidic growth pattern are classified as invasive lepidic predominant adenocarcinoma. OBJECTIVE: The aim of this study was to demon...

A Bioinformatics Analysis Based on Omics and Clinical Data for Graph-Based Patient Stratification in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most frequent and lethal malignancies worldwide, with substantial molecular and clinical heterogeneity that complicates prognostic assessment. We aimed to identify molecular subgroups with distinct prognostic profiles using a graph-bas...