Samarkand State Medical Institute

Cell-free DNA fragmentomics and epigenomic profiling in hematologic malignancies: current evidence, translational limitations, and future directions

Mutation-based liquid biopsy supports diagnosis and disease monitoring in hematologic malignancies, but interpretation of plasma variants may be complicated by clonal hematopoiesis, treatment-related changes, and nonmalignant blood-cell turnover. This structured narrative review...

ADHERENCE TO INFANT AND YOUNG CHILD FEEDING (IYCF) GUIDELINES AMONG MOTHERS ATTENDING A RURAL IMMUNIZATION CLINIC

The first one thousand days of life — from conception to a child's second birthday — shape health more powerfully than almost any other period. How infants and young children are fed during this window determines not only their survival but their growth, cognitive development, an...

A Prospective Clinical and Field Study Evaluating the Role of Salt Sensitivity Phenotyping in Guiding Antihypertensive Drug Selection and Reducing the Psychological Burden of Trial-And-Error Therapy

The objective of the prospective study was to investigate the significance of phenotypic characterization of salt sensitivity in the selection of initial antihypertensive therapy and its effect on blood pressure control among patients with stage 1 hypertension. Another aim was to...

A Clinical Validation Study and the Psychological Implications of Early Risk Detection: Predictive Biomarkers for Resistant Hypertension

The purpose of this prospective cohort study was to determine the predictive capability of a set of biomarkers to detect patients that will ultimately develop resistant hypertension. Another objective was also to evaluate whether early biomarker risk stratification could reduce t...

Synergistic Effects of Culturally Adapted Mindful Movement on Pain Catastrophizing and Physical Function in Chronic Low Back Pain: A Randomized Controlled Trial

The current research was done with the aim to identify the joint effect of mindful movement program adapted to culture and translated into Uzbek on pain catastrophization and physical function in patients with chronic non-specific LBP. The design of this study was randomized cont...

Understanding the Psychosocial Factors Affecting Hypertension Management in Vulnerable Populations

This study conducted, was cross-sectional and carried out using a mixed approach to explore psychosocial determinants associated with the treatment of hypertension among vulnerable individuals in Uzbekistan. From March to August 2025, 320 patients suffering from hypertension with...

COMBINED BOTULINUM TOXIN THERAPY AND PERCUTANEOUS TIBIAL NERVE STIMULATION IN THE REHABILITATION OF WOMEN WITH URGENCY URINARY INCONTINENCE ASSOCIATED WITH DIABETES MELLITUS.

OBJECTIVE: To evaluate the clinical efficacy and safety of a combined rehabilitation program consisting of intradetrusor injection of botulinum toxin type A followed by a course of percutaneous tibial nerve stimulation (PTNS) in women with urgency urinary incontinence associated...

A Psychosocial Perspective on Sedentary Behavior and Workplace Health: The Role of Physical Activity in Reducing Hypertension Risk Among Office Workers

The purpose of this study which has been done through a cross-sectional-analytic, was to examine the correlation between physical activity and the occurrence of hypertension among Jordanian office workers. Another objective of the research was to investigate the psychological and...

Negative Results in Narcissism Interventions: A Meta-Analytic Review of Replication Failures in Social Media De-Addiction Programs

This study aim to assess the true effect size of digital addiction cessation intervention in reducing narcissism as well as sources of heterogeneity and publication bias in this field. Meta-analysis of all relevant research that followed the PRISMA 2020 guideline was performed on...

SPECIFIC FEATURES OF ANESTHETIC MANAGEMENT IN PEDIATRIC MAXILLOFACIAL SURGERY

The article examines the specific aspects of anesthetic management during maxillofacial surgical procedures in children. Particular attention is given to age-related anatomical and physiological characteristics, the structure of the pediatric airway, metabolic differences, and in...

Mitochondrial fitness for sustainable male health – a 3PM-guided healthcare innovation

Abstract Male health is much more than only an essential pillar of the sustainable socio-demographic development of each society. To this end, erectile dysfunction, preventable male infertility, and urological cancers (including testicular, bladder, kidney, prostate, and penile o...

Time to pacemaker insertion in older adults: A perspective on mortality and functional outcomes

Pacemaker insertion is common in older adults, yet the implications of procedural delays remain unclear. Nguyen and colleagues reported that longer time to implantation was associated with increased mortality over nearly five years. While this contribution is valuable, several me...

Severe, delayed-onset thrombocytopenia after prolonged chlorothiazide use in a former preterm infant with bronchopulmonary dysplasia: a case report

Abstract Introduction Drug-induced immune thrombocytopenia (DITP) is a rare, antibody-mediated adverse effect that typically occurs within days to weeks of drug exposure and is rarely reported in infants receiving prolonged diuretic therapy. Case presentation We report a former 2...

Synthetic Biology and Soft Robotics in Biohybrid Kidney Replacement: A Conceptual Framework and Translational Roadmap

ABSTRACT Background Chronic kidney disease necessitates safer, more continuous kidney replacement therapies (KRT), yet current dialysis and transplantation are constrained by intermittent treatment, organ scarcity, and immunosuppression‐related complications. Methods This concept...

Altitudinal patterns of soil nematode community diversity and functional structure in the Boysun Mountains, Uzbekistan

Mountain ecosystems provide natural gradients for investigating biodiversity responses to environmental variation. This study examined the effects of altitude on the taxonomic diversity, trophic structure, and functional composition of soil nematode communities in the Boysun Moun...

Altitudinal patterns of soil nematode community diversity and functional structure in the Boysun Mountains, Uzbekistan

Mountain ecosystems provide natural gradients for investigating biodiversity responses to environmental variation. This study examined the effects of altitude on the taxonomic diversity, trophic structure, and functional composition of soil nematode communities in the Boysun Moun...

Design a Novel Recyclable Fe 3 O 4 @SiO 2 ‐TGDM@Ni MICOF Electrode for CO 2 Trap, Electrolyte, and Catalyst for Electro‐Carboxylation Reaction

ABSTRACT The design and development of high‐performance electrocatalytic systems featuring multiple functionalities, excellent recyclability, and reusability constitute a vital and essential advancement in the field of green chemistry. Such innovative approaches significantly mit...

The Transformation of the Microenvironment: From Observer to Coordinator in Monoclonal Gammopathy of Undetermined Significance (MGUS) to Myeloma Development

ABSTRACT Monoclonal gammopathy of undetermined significance (MGUS) is a common asymptomatic plasma cell disorder and the major precursor state of multiple myeloma (MM). Although progression is partly shaped by intrinsic genetic and epigenetic changes within the plasma cell clone,...

MORPHOLOGICAL AND MICROBIOLOGICAL CHANGES IN THE INTESTINAL TRACT FOLLOWING EXPERIMENTAL CHOLECYSTECTOMY

Gallstone disease (GLD) is a disease of the hepatobiliary system, characterized by the formation of changes in the internal bile ducts of the liver, the common bile duct, and the gallbladder. Gallstone disease, according to most statistical analyses, is more common in young and m...