Saitama Medical University

Successful staged anatomic repair for congenitally corrected transposition with both atrioventricular valves’ regurgitation: a case report

Abstract A 4-year-old boy with dextrocardia, congenitally corrected transposition of the great arteries, pulmonary valve stenosis, and ventricular septal defect demonstrated progressive hypoxemia and mild-to-moderate mitral and tricuspid regurgitation. Cardiac magnetic resonance...

ROC ‐Derived Age Threshold, Injury Mechanisms, and Fracture Patterns Associated With Severe Head and Neck Injury in Patients With Maxillofacial Fractures

BACKGROUND: Early identification of patients at risk of severe head and neck injury following maxillofacial fractures is essential for clinical management. However, chronological age alone may not reflect injury severity or physiological vulnerability. This study aimed to identif...

Tarlatamab in small cell lung cancer following platinum-based chemotherapy: subgroup analysis of Japanese patients from the DeLLphi-304 study

Abstract Background In the Phase 3 DeLLphi-304 trial, tarlatamab significantly improved overall survival (OS) over chemotherapy for small-cell lung cancer (SCLC) progressed after platinum-based chemotherapy. We report efficacy and safety in the Japanese subpopulation. Methods Pat...

Prospective Environmental Surveillance of Aspergillus spp. During Hospital Renovation: Evidence of Potential Fungal Dissemination Through Shared Ceiling Voids

Background: Hospital construction and renovation are recognized risk factors for healthcare-associated aspergillosis because demolition work can disperse airborne fungal spores into the air. However, environmental dissemination pathways during renovations remain incompletely unde...

Evaluation of the UK Myeloma Research Alliance risk profile in transplant‐ineligible multiple myeloma patients treated with novel agents

Summary The heterogeneity of multiple myeloma (MM) significantly impacts treatment outcomes. Myeloma risk profile (MRP), introduced by the UK Myeloma Research Alliance, is a novel prognostic model for patients with transplant‐ineligible newly diagnosed MM (TIE‐NDMM) utilizing eas...

Characteristics of Patients Achieving Clinically Meaningful Improvement in Neuropathic Pain After Surgery for Degenerative Cervical Myelopathy

Study DesignRetrospective analysis of a prospectively maintained multicenter cohort.ObjectivesTo identify clinical characteristics associated with clinically meaningful improvement in neuropathic pain and to evaluate its relationship with postoperative functional outcomes in pati...

Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI

BackgroundThe safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. MethodsWe conducted a multicenter, open-label, randomized trial in Japan i...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Influence of Anatomical Variations due to Horseshoe Kidney on Colorectal Cancer Surgery

BackgroundHorseshoe kidney is a rare renal fusion anomaly often associated with vascular and ureteral variations. Previous case reports have described technical considerations during colectomy in patients with horseshoe kidney. However, studies systematically evaluating the impac...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

SYK inhibitor fostamatinib promotes mitochondrial respiratory chain supercomplex formation and improves skeletal muscle function in aged mice

Mitochondria are major organelles involved in energy metabolism and play a crucial role in the function of muscular tissues. Mitochondrial respiratory chain (MRC) complexes are assembled to higher-order “MRC supercomplex (SC)” structures, which has been suggested to promote energ...

P1.231. Patients With Anastomotic Stricture After McKeown Operation for Esophageal Cancer Is Associated With Lower Rate of Recurrence: Retrospective Cohort Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background This was a single institutional retrospective study. Patients with esophageal squamous cell carcinoma who underwent esophagectomy with radical lymph node dissection reconstru...

P1.183. Salvage Surgery and Conversion Surgery for Esophageal Cancer in Patients Aged 80 Years or Older

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background With the rapid aging of the population, esophageal cancer in individuals aged 80 and older continues to increase. Conversely, with recent advances in multidisciplinary treatment, including novel...

P1.114. Endoscopic Diagnosis of Esophageal Cancer Using Ultra-High Magnification Endocytoscopy

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background Background Ultra-high magnification endoscopic observation using endocytoscopy (EC) enables cellular-level visualization and allows in vivo assessment comparable to histopa...

P1.232. Treatment Outcomes of Conversion Surgery for Advanced Esophageal Cancer Following ICI-Combined Chemotherapy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Immune checkpoint inhibitor (ICI)-based combination chemotherapy for advanced esophageal cancer demonstrates high response rates, enabling conversion surgery in some cases. H...

Comparison of response criteria in palliative radiotherapy for bleeding gastric cancer: A secondary analysis of the JROSG 17-3 multicenter prospective observational study

PURPOSE: In radiotherapy for bleeding gastric cancer, no standard response definition exists; studies have used transfusion-only or transfusion-plus-hemoglobin criteria. After inter-facility transfer or during home care-sometimes following palliative radiotherapy-laboratory resul...

How long can suction drains be safely retained after surgery for musculoskeletal malignant tumors?

In orthopaedic surgery, prolonged suction drainage has been associated with an increased risk of infection, and drain removal within 24 h is generally recommended. However, whether this recommendation applies to musculoskeletal tumor surgery, which is often more invasive and asso...

Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon‐Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement

ABSTRACT Aim Carbon‐ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X‐ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC). H...

Accurate Diagnosis of Atrioventricular Nodal Reentrant Tachycardia With Very Short His‐Atrial Interval and Earliest Activation in the Proximal Coronary Sinus

ABSTRACT Introduction Differential diagnoses in atrioventricular nodal reentrant tachycardia (AVNRT) with His‐atrial (HA) interval of < 70 ms and earliest atrial activation site (EAAS) in the proximal coronary sinus (pCS) include slow‐fast AVNRT with inferior deviation of the...