Saitama Cancer Center

OA03-RF01.10. Distinct Clinical Roles of CK7/CK20 and CDX2 Expression in Esophagogastric Junction Adenocarcinoma

Abstract Topic Esophageal Cancer: Esophageal Carcinogenesis Background Esophagogastric junction (EGJ) adenocarcinoma comprises tumors arising from distinct backgrounds, including Barrett’s esophageal adenocarcinoma and gastric cardia adenocarcinoma. Although CK7/CK20 expression p...

Nivolumab plus ipilimumab-based treatment in Japanese patients with metastatic non-small cell lung cancer and tumor PD-L1 < 1%: a pooled analysis

BACKGROUND: Nivolumab plus ipilimumab-based therapies have shown long-term, durable clinical benefit in patients with metastatic non-small cell lung cancer (NSCLC), including those with tumor programmed death-ligand 1 (PD-L1) expression < 1%, a population with high unmet need. He...

Circulating effector memory CD8 + T-cells predict tumor shrinkage and reflect wasting conditions and immunity in tocilizumab plus gemcitabine/nab-paclitaxel for mPDAC

Circulating levels of effector memory CD8 + T cells are associated with a better prognosis in patients with metastatic pancreatic ductal adenocarcinoma. The purpose of this study was to assess the effects of effector memory CD8 + T cells on tumor size and wasting conditions. In t...