Saint Louis University

Berberine as a Mitochondrial Metabolic Reprogrammer in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Adaptive Energetic Stress, Quality Control, and Translational Limitations

Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to mitochondrial dysfunction, including altered oxidative phosphorylation, disrupted fatty-acid oxidation, redox imbalance, abnormal mitochondrial dynamics, and impaired quality control. Berberine...

Environmental Impact Shaping a Firm's Zero Leverage Decision: Analysing Debt Demand and Supply Determinants

ABSTRACT Zero‐leverage firms remain a puzzle in corporate finance. We propose a supply‐side mechanism linking environmental impact to debt access. Because creditors favour firms with high negative externalities and strong cash flows, environmentally friendly firms with high initi...

A Hybrid Transfer Learning Approach for Ambient PM2.5 Exposure Modeling in LMIC Contexts: A Case Study from Lima, Peru

Abstract Exposure to fine particulate matter (PM2.5) contributes to millions of premature deaths annually worldwide. While epidemiological studies increasingly rely on geospatial technologies, such as satellite remote sensing, low-cost sensors, and chemical transport models, to q...

Cumulative lifetime trauma exposures in a nationally representative prison sample: findings from the mental health and substance use disorders prevalence survey

BACKGROUND: Trauma exposure is a driver of poor health, mental health, social and economic outcomes with a dose-response relationship between number of types of exposures and worse outcomes. This study explores the trauma exposure histories of individuals in prison, a population...

Centering Veteran expertise: advancing peer-led harm reduction in the Veterans health administration

Abstract The principle “Nothing about us without us” underscores the ethical imperative to involve people with lived and living expertise in shaping harm reduction praxis. While the United States Veterans Health Administration (VHA) has expanded harm reduction initiatives, such a...