Sainsbury Laboratory

Reciprocal connections dynamically build consensus between neocortical areas

Abstract The neocortex is organized into specialized areas. Although computations within individual areas have been well studied, it is unclear how these regions function collectively and reconcile potential conflicts to form coherent percepts and decisions. We investigated the j...

A disulfide bond sculpts the CTNIP4 phytocytokine fold for recognition by the receptor kinase HSL3

Abstract Precise ligand recognition by closely related leucine-rich repeat receptor kinases (LRR-RKs) is essential for plants to coordinate immunity, development and environmental adaptation. Here we show how the LRR-RK HSL3/NUT specifically recognizes the folded, disulfide-stabi...

Dissecting Maize Aerial Meristems

The plant kingdom displays a wide array of shapes, and this morphology is tightly linked to function and productivity. For example, leaf size, shape, and arrangement around the stem define canopy architecture, influencing light interception and photosynthetic capacity. Understand...

A conserved small RNA-generating gene cluster undergoes sequence diversification and contributes to plant immunity

Abstract Small RNA-mediated gene silencing contributes to plant immunity. The secondary small interfering RNA (siRNA) pathway promotes defense by silencing target genes in invading fungal and oomycete pathogens. Many secondary siRNAs are derived from transcripts potentially encod...

The Journal of Open Source Software - An Introduction and Recent Changes

The Journal of Open Source Software (JOSS; https://joss.theoj.org) publishes concise peer-reviewed articles describing open source research software. The review process is open, iterative and includes evaluation of the software and its related attributes. The primary objectives a...

Iron-responsive transcription factor SreA regulates calcium homeostasis independently of calcineurin–Crz1 pathway in Fusarium graminearum

ABSTRACT Calcium is an abundant intracellular ion that is intricately involved in various cellular processes. The precise regulation of calcium homeostasis is critical for fungal physiology. In fungi, calcium signaling is primarily mediated by the calmodulin–calcineurin pathway,...

Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics

Abstract Genetic circuits with only a few components can generate complex gene regulatory dynamics. Here, we combine stochastic modelling and single-cell time-lapse microscopy to reveal the possible dynamics generated by a key gene circuit motif: the mixed positive/negative feedb...

Tell Your Story: Strengthening Scientific Engagement and Welfare Leadership among Animal Technologists

<ns5:p>Background Animal Technologists (ATs) are vital in the scientific community, offering crucial expertise in animal care, welfare, and experimental procedures. As projects become more complex, there is an increasing opportunity for ATs to engage actively in scientific projec...