Sainsbury Laboratory

Iron-responsive transcription factor SreA regulates calcium homeostasis independently of calcineurin–Crz1 pathway in Fusarium graminearum

ABSTRACT Calcium is an abundant intracellular ion that is intricately involved in various cellular processes. The precise regulation of calcium homeostasis is critical for fungal physiology. In fungi, calcium signaling is primarily mediated by the calmodulin–calcineurin pathway,...

Mixed positive and negative feedback loops drive diverse single-cell gene expression dynamics

Abstract Genetic circuits with only a few components can generate complex gene regulatory dynamics. Here, we combine stochastic modelling and single-cell time-lapse microscopy to reveal the possible dynamics generated by a key gene circuit motif: the mixed positive/negative feedb...

Tell Your Story: Strengthening Scientific Engagement and Welfare Leadership among Animal Technologists

<ns5:p>Background Animal Technologists (ATs) are vital in the scientific community, offering crucial expertise in animal care, welfare, and experimental procedures. As projects become more complex, there is an increasing opportunity for ATs to engage actively in scientific projec...