Institution
Rutgers New Jersey Medical School
Recent research
- Health & Medicine
Gout May Mimic Infection, Even Years After Achilles Tendon Repair
BACKGROUND: Gout can affect tendons in addition to joints and may clinically resemble infection. The resulting diagnostic uncertainty may lead to surgical intervention or antibiotic treatment, even in patients whose symptoms might be managed medically if gout is recognized earlie...
- Health & MedicineOpen access
Interferon lambda (IFN-λ) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal deli...
- Health & Medicine
The silent pandemic: the overlooked toll of stroke compared to COVID-19
The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...
- Health & MedicineOpen access
Background The effects of co-existing OSA on the outcomes of ARDS are unclear. Objectives This retrospective study aimed to compare the outcomes and resource utilization rates of OSA patients who develop ARDS with a matched control group. Materials and methods Adult patients hosp...
- Health & MedicineOpen access
Abstract Fms-related receptor tyrosine kinase 3 (Flt3) is upregulated in ischemic hearts, yet its macrophage-specific role in post-ischemic remodeling remains unclear. Here, we identify macrophages as the predominant Flt3-expressing cells in the infarcted heart and demonstrate th...
- Health & MedicineOpen access
BACKGROUND: Postoperative radiotherapy (PORT) improves locoregional control and survival in high-risk head and neck cancer, and guidelines recommend initiation within 42 days of surgery. Timeliness after laryngectomy for pathologic T4 (pT4) laryngeal cancer is poorly characterize...
- Health & MedicineOpen access
Background Current guidelines recommend delaying elective surgery after coronary revascularization, but the relationship between timing for total joint arthroplasty (TJA) and postoperative outcomes remains unclear. We investigated the association between timing of TJA after percu...
- Society & EconomicsOpen access
Closing the Gaps: Behavioral Health Screening Intervention and Follow-Up in a Level I Trauma Center
Introduction Substance misuse (SM) and mental health (MH) disorders are highly prevalent among trauma patients and are associated with increased mortality and recurrent injury. Despite national guidelines mandating behavioral health screening of at least 80% of admitted patients...
- Health & MedicineOpen access
Tumor-infiltrating tissue-resident memory (TRM)-like CD8+ T cells correlate with positive prognosis and better responses to cancer immunotherapy, yet the mechanisms underlying their specification remain ill-understood. Here, we use the KP (KrasG12D, p53-/-) mouse model of lung ad...
- Health & MedicineOpen access
Penetrating injury to the dural venous sinuses (DVS) commonly occurs at the superior sagittal sinus (SSS), transverse sinus (TS), and torcular confluence. While rare, DVS penetrating injuries carry high risk of intracranial hemorrhage, air embolism, and venous infarction. The cur...
- Society & EconomicsOpen access
Abstract Immigration enforcement increasingly intersects with healthcare delivery, creating clinical situations that may affect immigrant patients’ access to care, trust in healthcare institutions, and interactions with physicians. Despite these challenges, formal training on imm...
- Society & Economics
Examining Practice and Payment Gaps in Otolaryngology: Evidence from US Medicare Data
Abstract Objective To assess longitudinal differences in Medicare reimbursement, billing patterns, and service composition among US otolaryngologists. Study Design Retrospective cohort study. Setting Centers for Medicare & Medicaid Services (CMS) Medicare fee‐for‐service database...
- Health & Medicine
Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths
Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...
- Health & Medicine
Updated Incidence of Suicide Among Patients With Head and Neck Cancer
OBJECTIVE: To assess incidence, temporal trends, and risk factors for suicide among patients with HNC using Surveillance, Epidemiology, and End Results (SEER) data. METHODS: A total of 222,222 patients were diagnosed with HNC from the SEER 17 registries between 2012 and 2021. Sui...
- Health & MedicineOpen access
Autoimmune diseases frequently involve the gastrointestinal (GI) tract and can present with nonspecific symptoms that delay diagnosis. Their manifestations range from subtle motility disturbances to life-threatening ischemia, perforation, or obstruction. Advances in cross-section...
- Health & MedicineOpen access
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, cartilage degradation, and bone erosion. Fibroblast-like synoviocytes (FLS) play a central role in perpetuating joint damage, yet current therapies inadequately address FLS-driven pa...
- Health & MedicineOpen access
Adoptive cellular therapies may expand treatment options for pediatric brain tumors by focusing activity on tumor antigens and limiting off-tumor effects. We systematically reviewed preclinical and clinical evidence for CAR T cells, TCR-engineered T cells, and NK or γδ T-cell pla...