Russian Cancer Research Center NN Blokhin

Microsurgical resection of brain metastases: rationale, appropriateness and local control

OBJECTIVE: To summarize data on indications for microsurgical resection of brain metastases, effect of resection technique on local control and leptomeningeal dissemination, as well as the role of stereotactic radiosurgery in improving local control. MATERIAL AND METHODS: A descr...

Re-Evaluating Multi-Kinase Inhibitors Targeting FGFR and VEGFR Pathways for Combined Therapy in Colorectal Cancer: A Preclinical Study

Background: Overexpression and increased activity of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1/P-gp), breast cancer resistance protein (ABCG2/BCRP), and multidrug resistance-associated proteins (ABCC/MRPs), are known to be among the major contributors...

Linking In Vivo Imaging to Therapeutic Outcome with 131I, 177Lu, 188Re Nanoparticles

Nanoparticles are increasingly explored as carriers for therapeutic radionuclides in oncology, offering prolonged circulation, high payload capacity, and active targeting. Radiolabeling enables non-invasive tracking of these constructs by SPECT or PET, providing biodistribution d...

The Effect of Low-Intensity Laser Irradiation on GAP-43 Expression in the Hippocampus of Rats

A study was conducted to examine the effects of visible red light phototherapy with a wavelength of 635 nm on the expression of the neuronal protein GAP-43 in the hippocampus of rats. It was shown that the use of PBMT promotes increased GAP-43 synthesis in the hippocampus, with t...