Institution
Ruijin Hospital
Recent research
- Health & Medicine
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The clinical significance of supraclavicular lymph node (SCLN) involvement in esophageal cancer remains controversial. The role of surgery in managing patients with SCLN metastases remains uncertain....
- Health & MedicineOpen access
This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targ...
- Biology
Background and Objectives: No unified consensus exists regarding standardized protocols for single-cell RNA sequencing (scRNA-seq) analysis of samples obtained via EUS-guided fine-needle aspiration (EUS-FNA). This study aimed to evaluate the feasibility of applying scRNA-seq to E...
- BiologyOpen access
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury
Sepsis associated-acute kidney injury (SA-AKI), a severe complication of sepsis, is characterized by impaired tubular injury that can ultimately cause renal failure and patient mortality. Both histone and non-histone lactylation and cellular PANoptosis have been implicated in the...
- Health & MedicineOpen access
Noninvasive 3D mapping of tissue stress using reverberant shear wave
Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...
- Health & MedicineOpen access
Diabetes mellitus erectile dysfunction (DMED) is frequently accompanied by corpus cavernosum (CC) fibrosis and endothelial dysfunction; however, the cellular drivers and molecular mechanisms underlying these pathological changes remain incompletely understood. Endothelial-to-mese...
- Materials & EnergyOpen access
Advancing Energy Efficiency in Smart Windows via Dual‐Responsive Electro‐Thermochromism
ABSTRACT Implementing dynamic smart windows is imperative toward the construction of net‐zero buildings. However, the prevailing ion (de‐)embedding‐based electrochromic (EC) or thermosensitive hydrogel‐based thermochromic (TC) windows fail to achieve large optical modulation acro...
- Engineering & Technology
Abstract Urinary tract infections (UTIs) are among the most common bacterial infections in neonates and infants, and delayed diagnosis can lead to severe complications. Rapid, quantitative detection of viable bacteria at the point of care remains a critical unmet need. Here, we p...
- Biology
Although reperfusion therapy effectively restores blood flow to occluded brain arteries after ischemic stroke, many patients develop persistent white matter injury, a major contributor to long-term neurological disability. Currently, there are few approved clinical therapies that...
- Health & MedicineOpen access
Abstract Objective: The China Pancreas Data Center (CPDC) was established in 2015 with the support of the Chinese Pancreatic Surgery Association, Chinese Society of Surgery, Chinese Medical Association and initiated prospective data collection in 2017. This article reports contem...
- Health & MedicineOpen access
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...