Ruijin Hospital

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Abstract The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the therapeutic pathway and the imaging ta...

Clinical management of relapse in type 1 autoimmune pancreatitis: a systematic review and meta-analysis

Objectives: Type 1 autoimmune pancreatitis (AIP) has a high risk of relapse, but evidence to guide management is limited. We evaluated relapse patterns, predictors, and the comparative effectiveness of maintenance and relapse treatment. Methods: We systematically reviewed studies...

Federated knowledge-guided 3D Transformer learning for bone tumor segmentation from partially annotated computed tomography data

Accurate 3D delineation of bone tumors and metastatic lesions from volumetric CT is essential for diagnosis, staging, radiotherapy planning, and treatment monitoring, yet manual contouring is time consuming and variable across observers. Although modern 3D CNN/Transformer segment...

Prognostic Value of Intraoperative Desmopressin Test for Long-Term Remission in Cushing's Disease: A Prospective Cohort Study

BACKGROUND AND OBJECTIVES: The desmopressin stimulation test is a cornerstone for the diagnosis of Cushing's disease (CD). Recent evidence suggests its potential for early recurrence prediction when performed postoperatively. However, its application as a real-time intraoperative...

Low‐Temperature Demulsification‐Induced Gelation Coupled With Gel‐Confined Freeze Casting for Highly Elastic Conductive Aerogels in Wireless Gait Monitoring

ABSTRACT Polymer‐based conductive aerogels are promising for flexible piezoresistive sensors but suffer from skeleton deformation and conductive filler detachment under high‐strain and long‐term compression. Here, an aminopropyltriethoxysilane/carboxylated carbon nanotubes/waterb...

ANGPTL4 is a hypoxia associated candidate linked to immune and vascular phenotypes in ccRCC

Clear cell renal cell carcinoma (ccRCC) is characterized by prominent vascularization and cellular heterogeneity, but reliable biomarkers for angiogenesis and response to targeted therapy remain limited. In this study, transcriptomic data from GEO cohorts (GSE53757, GSE66271, GSE...

Targeting the NOTCH1 signaling pathway in chronic lymphocytic leukemia enhances the efficacy of CD19 CAR-T cells

Abstract Background The therapeutic efficacy of chimeric antigen receptor T (CAR-T) cells targeting CD19 in chronic lymphocytic leukemia (CLL) treatment can be limited by target cell antigen loss. This study aims to elucidate how the intrinsic NOTCH1 signaling activity in CLL cel...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...

Non-apnea electrical impedance tomography for bedside ventilation–perfusion assessment during spontaneous breathing: a prospective cross-over validation study

Conventional saline-contrast electrical impedance tomography (EIT) perfusion imaging typically requires a brief end-expiratory apnea during saline injection to reduce respiratory interference. However, this maneuver is often difficult or impractical in spontaneously breathing pat...

Multicenter Evaluation of Large Language Models Versus Hepatologists for Prognostic Prediction in Drug‐Induced Liver Injury

BACKGROUND & AIMS: Drug-induced liver injury (DILI) would progress to chronicity or death. Large language models (LLMs) may enhance clinical decision-making, yet their utility relative to physicians in DILI remains unclear. Therefore, we evaluated their performance in predicting...

Ultrasound‐Triggered Tendon–Bone Comb With Axially Graded Electrical Gradients for Tendon–Bone Interface Integration

ABSTRACT Loss of electrophysiological guidance from endogenous fibrous‐channeled electrical conduction critically impairs repair of the injured tendon–bone interface (TBI). Clinical analysis indicates that the inconsistent efficacy of conventional electrostimulation (ES) therapy...

Diagnosis of pleural mesothelioma via thoracoscopic visceral pleural snare biopsy: a case report

To evaluate the diagnostic efficacy of thoracoscopic visceral pleural snare biopsy for pleural mesothelioma (PM). We present a diagnostically complex case of recurrent right pleural effusion that was ultimately confirmed as PM through thoracoscopic visceral pleural snare biopsy,...

Coronary atherosclerosis, myocardial perfusion, and interstitial fibrosis between diabetic and nondiabetic patients with stable chest pain: a propensity score matching study

OBJECTIVES: To evaluate the effect of diabetes mellitus on coronary atherosclerosis, myocardial perfusion, and interstitial fibrosis using cardiac CT. METHODS: This study included 409 diabetic patients with stable chest pain who prospectively underwent coronary CT angiography (CC...

Cu-deficient Cu–Fe Prussian blue analogues enable phosphate/GSH-coupled redox remodeling for catalytic/sonodynamic cancer therapy

Cu–Fe Prussian blue analogues (PBAs) are promising platforms for nanocatalytic medicine owing to their redox-active Cu/Fe centers and open metal–cyano coordination frameworks. Nevertheless, the influence of Cu deficiency on their enzyme-mimetic catalytic behavior in tumor-relevan...

Integrated machine learning and clinical validation identify COL21A1 as a potential biomarker for sarcopenia

Sarcopenia is a progressive skeletal muscle disorder characterized by loss of mass, strength, and function. However, reliable molecular biomarkers for early detection remain limited. This study aimed to identify and validate potential biomarkers for sarcopenia through a combinati...

Associations of menstrual cycle length with GDM and gestational hypertension in frozen embryo transfer

Prolonged menstrual cycles may indicate potential cardiometabolic conditions; however, there are limited data on how these associations vary among women without polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF). In this study, we aimed to investigate the as...

Atractylodis Rhizoma-derived nanovesicles suppress adipocyte IDO1/kynurenine-AhR-androgen receptor signaling in a mouse model of obesity-associated PCOS

Abstract Background Obesity-associated polycystic ovary syndrome (PCOS) is characterized by metabolic dysfunction, adipose inflammation and androgen excess, but the adipose mechanism linking metabolic stress to androgen-related pathology remains unclear. This study aimed to deter...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Endothelial function in relation to low-level chronic residential air pollution in a general population: a cohort study

Background Given the recently updated clean-air targets, this population study assessed endothelial function at low exposure to particulate matter with an aerodynamic diameter of ≤10 µm (PM10) and ≤2.5 µm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC).Methods In 453 Flemi...

Hemodynamics and Renin Profiles of Renal Artery Variations in Hypertensive CKD

BACKGROUND: The functional implications of renal artery variations—including accessory renal artery (ARA) and early branching—in hypertensive chronic kidney disease remain poorly understood. METHODS: This prospective cohort study enrolled 38 patients with hypertensive chronic kid...