Ruian People's Hospital

Molecular Insights into the Bacterial Membrane Interactions of Proline-Stabilized Graphene: Effects of Proline Oligomerization

Abstract Multidrug-resistant bacterial infections pose a major global health challenge. Graphene nanosheets exhibit promising antibacterial activity through membrane disruption, but their practical application is limited by poor aqueous stability and biocompatibility. A recent st...

XPR1 Promotes the Malignant Phenotypes of Thyroid Carcinoma Cells Partly Through NF-κB-Related Signaling

Background: Xenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in human thyroid carcinoma (TC), yet its functional role remains unclear. In this study, we sought to determine whether XPR1 participates in the progression of thyroid carcinoma and to further...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Smart nanoparticle-assisted nucleic acid delivery for targeted therapy and tissue repair

Tissue repair necessitates precise temporal regulation of cell proliferation, differentiation, and angiogenesis. Nucleic acid drugs exhibit significant therapeutic potential, but they encounter challenges such as low delivery efficiency, nuclease degradation, poor membrane penetr...