Royan Institute

Adiponectin-enriched liver-derived ECM attenuates fibrogenic features of activated hepatic stellate cells in a multicellular 3D model

Abstract Background Adiponectin (ADPN), an adipocytokine expressed in multiple tissues including the liver by quiescent hepatic stellate cells (HSCs) has recognized antifibrotic properties. However, most studies rely on simplified 2D systems that fail to capture the liver microen...

The effects of royal jelly consumption on glycemia indices, lipid profile, and blood pressure in patients with acute ischemic stroke: a randomized, triple-blind trial

Abstract Aims The effects of royal jelly (RJ) on cardiometabolic risk factors in patients with acute ischemic stroke have not been previously reported from this trial. Therefore, we conducted a secondary analysis to investigate the effects of RJ consumption on glycemic indices, l...

Graded Levels of Dietary Valine in Protein‐Restricted Diets: Effects on Reproductive Performance and Tissue Morphology in Laying Japanese Quail

BACKGROUND: Valine (Val) is an essential branched-chain amino acid that plays a critical role in protein synthesis and reproductive function in poultry. However, the optimal dietary Val requirement for laying Japanese quail fed reduced-protein diets remains insufficiently defined...