Royal Perth Hospital

Characteristics and outcomes of patients admitted for suspected sepsis

Structured sepsis screening and management tools are associated with improvements in processes of care. Evaluating effects on clinical outcomes is challenged by the potential limitation of capturing a broader group of patients with less severe illness. The aim was to determine th...

Predicting recovery outcomes following mild traumatic brain injury in an Australian community cohort: Results from the Concussion Recovery Study (CREST)

Background Most people recover well following mild traumatic brain injury (mTBI). However, some experience persisting post-concussion symptoms (PPCS) for months or years. Our aims were (i) to evaluate the presence and impact of PPCS on return to functional activities over a 12-mo...

PET/CT-first staging in anal cancer: reconsidering the role of routine MRI

Multimodal imaging with pelvic MRI and FDG PET/CT is currently recommended for staging anal squamous cell carcinoma (ASCC). However, accumulating data suggest that PET/CT frequently alters staging and radiotherapy planning, raising questions about whether routine MRI is necessary...

How to Do a Laparoscopic Iliac Lymph Node Biopsy Under Indocyanine Green ( ICG ) Guidance

ABSTRACT Isolated abdominal lymphadenopathy can be difficult to diagnose when lesions are inaccessible to percutaneous biopsy. We describe a laparoscopic common iliac lymph node biopsy performed using indocyanine green (ICG) fluorescence guidance. A 67‐year‐old woman with bilater...

A qualitative analysis to identify implementation strategies for a deprescribing clinical practice guideline using the CFIR-ERIC Matching Tool: perspectives from consumers and professional stakeholders

Abstract Introduction Deprescribing is the planned withdrawal or dose reduction of medicines when harms outweigh benefits or when they are no longer required. Following publication of the Clinical Practice Guideline for Deprescribing in Older People in September 2025, supporting...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...