Royal Oak Community Coalition

Nipsnap 1 deficiency shifts neuronal and synaptic signaling toward inflammatory pathway and impairs cognitive functions in the aging brain

Mitochondrial quality control is essential for maintaining neuronal function during aging. Nipsnap1 (Nip1), a mitochondrial protein involved in mitophagy, metabolic regulation, and cellular senescence, has emerged as a potential regulator of tissue homeostasis; however, its role...

Long-Term Prosthesis Survival After Total Hip Arthroplasty in Young Women with Developmental Dysplasia of the Hip: A Narrative Review of Instability, Revision Risk, and Reproductive Health Considerations

Background/Objectives: Total hip arthroplasty (THA) reliably improves pain and function, but implant longevity in women aged ≤50 years is influenced by longer duration of implant use and distinct failure mechanisms. Developmental dysplasia of the hip (DDH) is a common underlying...

Analysis of serum NMR metabolomics in fibrotic diseases of the myocardium

INTRODUCTION: Heart failure accounts for more than 43% of annual deaths worldwide, and isdriven by widespread pathological remodeling, in which myocardial fibrosis plays an important role. Currently, accurate clinical diagnosis of myocardialfibrosis (MF) remains difficult, with e...