Royal North Shore Hospital

Circulating biomarkers in the diagnosis and management of neuroendocrine neoplasms

Abstract Neuroendocrine neoplasms (NENs) comprise a broad family of tumours arising from the diffuse neuroendocrine system and endocrine glands, and vary widely in clinical behaviour ranging from indolent to highly aggressive. Established monoanalyte biomarkers including chromogr...

Validation of the PANAMA Score in Patients With Pancreatic Ductal Adenocarcinoma Undergoing Distal Pancreatectomy

ABSTRACT Background The PANAMA score was developed as a post‐NAT prognostic tool for PDAC. Prior validations have been dominated by pancreatic head cancers. Pancreatic body and tail tumours represent a biologically distinct subgroup and remain underrepresented in NAT cohorts. Whe...

Evaluating the use, acceptability, usability, and perceptions of melanoma risk prediction tools for estimating melanoma risk among the community and patients in Australia: a mixed methods study

Abstract Background To identify high-risk individuals, melanoma risk prediction tools have been developed. However, little is known about their use in practice by patients and the community. We assessed the use, usability and acceptability of two validated melanoma risk predictio...

Irritability: what, who, how and why?

Irritability is a ubiquitous clinical phenomenon, and yet its definition and specific role within psychiatric disorders have long eluded the field. By understanding what irritability is, in whom it should be studied and how it should be modelled, new insights into the disorders w...

Association of Oral Health Assessment Tool Findings With Periodontal Screening Outcomes in Adults With Diabetes

ABSTRACT Background Periodontal disease is common among adults with diabetes, yet periodontal screening is rarely incorporated into routine outpatient diabetes care. The Oral Health Assessment Tool (OHAT) is a structured observational tool designed for non‐dental healthcare profe...

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants

Importance The optimal initial fraction of inspired oxygen (F io 2 ) for delivery room resuscitation of neonates born at 32 to 35 weeks’ gestation is unknown. Objective To compare outcomes for neonates born at 32 to 35 weeks’ gestation when initiating resuscitation with F io 2 0....

A cost-effectiveness analysis of selective decontamination of the digestive tract in mechanically ventilated patients in the intensive care unit

Objective To evaluate the 24-months cost-effectiveness of selective decontamination of the digestive tract (SDD) versus standard care in mechanically ventilated Intensive Care Unit (ICU) patients. Design Within‑trial cost‑effectiveness analysis using linked administrative healthc...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

BACKGROUND: Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and atte...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

Effects of mandibular advancement device versus continuous positive airway pressure on cardiac remodeling in obstructive sleep apnea: a randomized CMR substudy

Obstructive sleep apnea (OSA) is associated with adverse cardiac remodeling, including diffuse myocardial fibrosis. Continuous positive airway pressure (CPAP) is the standard treatment for OSA, while mandibular advancement devices (MAD) may represent an alternative. However, thei...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Cardiovascular Risk Prediction with the Kidney Failure Risk Equation in the Chronic Renal Insufficiency Study

Background: The Kidney Failure Risk Equation (KFRE) is an established tool to predict the risk of kidney failure among patients with CKD. Patients with CKD more often die from cardiovascular (CV) causes than renal causes, and more often experience a non-fatal CV event than progre...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

Neurocognitive outcomes after treatment of unruptured anterior communicating artery aneurysms – a systematic review

Cognitive changes after treatment of ruptured anterior communicating artery (AComA) aneurysms have been recognized for decades. Whether such deficits occur after elective treatment of unruptured aneurysms remains uncertain. A systematic search in MEDLINE (via PubMed and via Ovid)...