Institution
Royal Brompton Hospital
Recent research
- Health & MedicineOpen access
Abstract Rationale and Objective We assessed whether an FDA-cleared quantitative CT (qCT) tool (Brainomix, e-Lung) identifies progressive pulmonary fibrosis (PPF) earlier than routine clinical diagnosis and evaluated the prognostic value of baseline and serial imaging biomarkers....
- BiologyOpen access
Dynamics of human cardiogenesis and its disruption in trisomy 21
Abstract Developmental dynamics involve the specification of diverse cell types and their spatial organization into multicellular niches 1 . Here we combine single-cell and spatial multiomics to define 21 distinct tissue niches in the developing heart, which we use to develop a c...
- Health & Medicine
Congenital heart disease in adults: evolving health systems and lifelong outcomes.
Over the past decades, advances in the diagnosis and treatment of congenital heart disease have reshaped its epidemiology. Congenital heart disease is now increasingly a chronic, lifelong disorder, with adult survivors outnumbering affected children in many countries. This demogr...
- Health & MedicineOpen access
Immunotherapy-Related Cardiac Arrythmias: Incidence, Pathobiology, Risk Factors and Management
Abstract Purpose of Review Immunotherapies have revolutionized treatment strategies for cancer patients, improving the prognosis in many populations with advanced malignancies. Immune check point inhibitors (ICI) and Chimeric antigen receptor (CAR) T cell therapy are being increa...
- Health & MedicineOpen access
OBJECTIVE: A recently proposed uric acid index combining fasting glucose, triglycerides, and uric acid has shown promise in cardiovascular risk stratification. It was assessed whether the index could predict significant coronary artery stenosis (≥50%) on coronary computed tomogra...
- Health & Medicine
Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...
- Health & Medicine
BACKGROUND: The diagnostic value of coronary computed tomography angiography–derived fractional flow reserve (FFR-CT) in stable coronary artery disease is well established. The prognostic value of predicting future cardiovascular events is less clear, as studies are limited by sm...
- Health & MedicineOpen access
Consensus recommendations for standardising ILD multidisciplinary discussions in India
Abstract Background Interstitial lung diseases (ILDs) are complex, heterogeneous disorders that require accurate diagnosis and coordinated care. Multidisciplinary discussions (MDMs) are considered the gold standard for ILD management; however, in India, the implementation of stru...
- Health & Medicine
Diving-related ear, nose, and throat disorders: a structured review using a phase-of-dive framework
Introduction: The aim of this review was to synthesise evidence on ear, nose, and throat (ENT) and related head and neck complications in scuba divers, with emphasis on mechanisms of injury, dive phase-specific risk patterns, and implications for clinical management and fitness-t...
- Health & MedicineOpen access
Novel Interventional and Surgical Therapies in Chronic Obstructive Pulmonary Disease
Abstract Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with its global prevalence projected to increase substantially by 2050, making its management one of the greatest challenges in respiratory medicine. Although pharmacological and...
- Health & MedicineOpen access
Diffusion in deforming semi-permeable media: a Monte Carlo random walk approach
Abstract Diffusion processes in deforming media with semi-permeable barriers are fundamental to understanding many biological and physical systems. The presence of semi-permeable barriers causes temporal and spatial departures from normal diffusion. We present an analytic express...