Royal Brompton & Harefield NHS Foundation Trust

Acute heart failure in emergency settings

Abstract Acute heart failure (AHF) represents a major cause of emergency medical care worldwide and continues to carry a substantial burden of morbidity and mortality despite advances in chronic heart failure management. Most patients with AHF present to emergency departments (ED...

Adults with congenital heart disease: the growing impact of acquired cardiovascular risk factors on late mortality.

BACKGROUND AND AIMS: With improved survival, adults with congenital heart disease (ACHD) increasingly face acquired cardiovascular risk factors; however, their impact on late mortality remains incompletely defined. This study aimed to evaluate the contribution of acquired cardiov...

Radiomics machine learning models for lung cancer early diagnosis in heterogenous multicentre chest CT data: LIBRA study results

Abstract Objective We developed and validated radiomics models for lung cancer prediction in indeterminate pulmonary nodules that retain performance in heterogenous data from multiple centres. Materials and methods The retrospective Lung Imaging Biobank for Radiomics and AI (LIBR...

An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy

BACKGROUND: Evidence of the diverse genetic architecture of dilated cardiomyopathy (DCM) continues to emerge and requires reassessment of the clinical relevance of implicated disease genes. Building on the 2019-2020 Clinical Genome Resource evaluation, the DCM gene curation exper...