Royal Adelaide Hospital

Circulating biomarkers in the diagnosis and management of neuroendocrine neoplasms

Abstract Neuroendocrine neoplasms (NENs) comprise a broad family of tumours arising from the diffuse neuroendocrine system and endocrine glands, and vary widely in clinical behaviour ranging from indolent to highly aggressive. Established monoanalyte biomarkers including chromogr...

Validation of the International Working Group 2023 response criteria for higher risk myelodysplastic syndromes/neoplasms using the International Consortium for Myelodysplastic Syndromes VALIDATE database and a randomized phase III trial

Response assessment criteria in patients with higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) have been updated in the 2023 International Working Group (IWG) criteria. However, validation of these criteria has been limited to date. We analyzed overall survival (OS) by be...

Kidney Donation After Circulatory Death Is Associated With Sustained Graft Function, Comparable Graft, and Patient Survival.

Background: Kidney transplantation is the preferred treatment for kidney failure, offering various benefits, yet donor supply remains limited worldwide, including in Australia and New Zealand. We examined long-term outcomes of kidney transplant recipients from donation after circ...

The feasibility of a tailored follow-up service for people living with stroke via a registry-based randomised controlled trial (A-LISTS)

After stroke, people report ongoing health challenges to national registries without any follow-up. We aimed to assess the feasibility of a co-designed, registry-initiated, follow-up service provided by hospitals and tailored for people reporting health-related challenges between...

Quantitative single cell analysis of gold nanoparticle association across a mouse triple-negative breast cancer cell line and blood immune cell populations

In biomedical research, understanding the heterogeneity in nanoparticle association among different cell populations is crucial for translating to efficacy and immune identification. Using time-of-flight mass cytometry (CyTOF), we quantitatively assessed the association and distr...

Insulin‐Like Growth Factor Axis and Survival in Metastatic Hormone‐Sensitive Prostate Cancer: Post‐Hoc Analysis From the ENZAMET Phase 3 Trial

ABSTRACT Background A higher ratio of IGF‐1:IGF binding protein 1 (IGFBP1) was associated with improved prognosis in the CHAARTED trial of docetaxel in participants with metastatic hormone‐sensitive prostate cancer (mHSPC). The ENZAMET trial demonstrated the survival benefit of a...

Determining the Number of Chronic Subdural Hematoma Potentially Eligible for Middle Meningeal Artery Embolization: A Population-Based Study

BACKGROUND: Middle meningeal artery embolization (MMAE) was recently proven to be an evidence-based adjunct to burr-hole drainage for chronic subdural hematoma (CSDH). Population-level estimates of patients with CSDH potentially eligible for MMAE are lacking, limiting rational se...

Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis

Objective To quantify exercise dose-response relationships and estimate the optimal dose in adults with chronic low back pain disorders (CLBDs). Design Systematic review with random-effects model-based (non-linear) dose-response network meta-analysis. Risk of bias was assessed wi...

Trends of sexually transmitted infections among pregnant women in Melbourne, Australia, 2012–2025: a rise in burden of syphilis

BACKGROUND: Sexually transmitted infections in pregnancy threaten both mother and baby, so early detection matters. This study aimed to describe the epidemiology and temporal trends of sexually transmitted infections (STIs) among pregnant women attending a large public sexual hea...

Survival among patients with systemic sclerosis‐associated pulmonary arterial hypertension in the Australian scleroderma cohort study

BACKGROUND AND AIMS: Systemic sclerosis (scleroderma; SSc) patients can develop pulmonary arterial hypertension (PAH), which is a leading cause of death. We sought to evaluate severity, therapeutic strategy and survival of SSc-PAH in the Australian Scleroderma Cohort Study (ASCS)...

Sarcopenia and Skeletal Muscle Dysfunction in Liver Cirrhosis: Clinical Perspectives of Myostatin Inhibition

Liver cirrhosis is frequently complicated by sarcopenia, a progressive and systemic loss of skeletal muscle mass and function that contributes substantially to increased morbidity, mortality, and healthcare utilisation. The pathogenesis of sarcopenia in cirrhosis is multifactoria...

Implementation of a Structured Hot Debrief Tool in a Metropolitan ED : A Quality Improvement Study

OBJECTIVE: To evaluate the acceptability and feasibility of implementing a structured 'hot debrief' tool, and its impact on team effectiveness, staff well-being and identification of system-level issues following critical events in two EDs. METHODS: We conducted a multi-site qual...

ANZTCT cytomegalovirus practice survey for allogeneic haemopoietic stem cell transplant and cellular therapy recipients in Australia and New Zealand

BACKGROUND: Despite pre-emptive treatment (PeT), cytomegalovirus (CMV) disease and reactivation remain a clinical concern. In Australia and New Zealand (ANZ), variability exists in the management of CMV for haematopoietic stem cell transplantation (HSCT) recipients. AIMS AND METH...

Sclerotherapy in Orbital and Peri-Orbital Pathology: A Systematic Review of Current Applications and Emerging Frontiers

Aim To highlight current and emerging applications of sclerotherapy in orbital and peri-orbital pathology while identifying evidence gaps and future directions.Methods Systematic review of 108 studies identified through PubMed, Embase, Scopus, and Web of Science databases from in...

The Pear Strategy for Two‐Ring Pulmonary Vein Isolation: Antral and Sleeve Ablation Using a Balloon‐in‐Basket Pulsed Field Ablation Catheter

ABSTRACT Background Pulsed field ablation (PFA) has emerged as a promising energy source for atrial fibrillation (AF) catheter ablation. This study aimed to describe the adoption and workflow optimization of a novel balloon‐in‐basket PFA catheter using a two rings balloon and pea...

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

BACKGROUND: Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and atte...

The increasing burden of revision arthroplasty for infection and fracture: perspectives of a tertiary referral centre

Background: In public hospitals the number of complex urgent and semi-urgent revision joint replacements has increased over time, conversely the number of primary joint replacements has decreased. This study aimed to investigate the effect of this change on service delivery of el...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

The effect of augmented protein intake on nitrogen balance: A nested cohort study of the TARGET protein trial

Purpose The impact of augmenting enteral protein delivery on nitrogen balance, urea generation, and kidney function in critically ill patients remains poorly defined. This study aimed to investigate these effects in a nested cohort within the TARGET Protein trial. Methods We cond...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...