Roslin Institute

Viperin as a putative antiviral effector in rainbow trout (Oncorhynchus mykiss) cells identified by CRISPR-Cas9 functional analysis following exposure to inactivated viral hemorrhagic septicemia virus

Abstract Viperin is recognized for its potent broad-spectrum antiviral activity; however, its role in the antiviral immune response of rainbow trout ( Oncorhynchus mykiss ) remains poorly characterized. In this study, the contribution of viperin to the innate immune response agai...

Social communication during a sow-piglet foraging paradigm

Offspring may use various sensory modalities to learn from the mother, but this has in pigs received relatively little research attention. The objective of this study was to investigate social cues between sow and piglet during a learning scenario related to foraging. We hypothes...

Quantifying welfare impairment from respiratory disease in fattening pigs using adaptive conjoint analysis

Abstract Respiratory disease remains highly prevalent in pig production and constitutes a major health and welfare challenge worldwide. However, most studies assessing pig welfare impairment from respiratory disease rely on isolated animal-based indicators, limiting integration a...

Evaluating Selection Strategies Based on Inbreeding Load via Simulation

Inbreeding load is the fraction of the mutation load that is due to recessive action of mutations. This load is only expressed in individual's inbred offspring. As such, inbreeding load contributes to genetic heterogeneity among individuals and can thus be used as a criterion of...

Faecal IgA but not salivary IgA is associated with canine atopic dermatitis

Objectives To characterise immunoglobulin A (IgA) levels in the faeces and saliva of dogs with canine atopic dermatitis (CAD) and healthy breed matched controls. Materials and Methods Dogs with canine atopic dermatitis were recruited based on history, clinical examination and dia...

Complex linkage disequilibrium and quantitative trait loci in chicken

Abstract Linkage disequilibrium (LD) underpins mapping studies of Quantitative Trait Loci Regions (QTLRs). A common yet misled assumption assumes the closest sites to a significant marker as causative mutation candidates. We studied chicken LD of mapped chicken QTLRs for Marek’s...