Robert H. Lurie Comprehensive Cancer Center of Northwestern University

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Effects of Palliative Oral Etoposide on Survival and Treatment Burden in Patients With Relapsed/Refractory Pediatric Malignancies

Oral etoposide has been given as palliative treatment for pediatric patients with relapsed/refractory malignancies. There is limited literature regarding the efficacy of oral etoposide for relapsed/refractory pediatric malignancies, and even less on its treatment burden for patie...

National Outcomes of Sepsis in Publicly Insured Children: 2021–2023

OBJECTIVE To identify incidence and factors associated with sepsis mortality. METHODS We conducted a cohort study of all US publicly insured children younger than age 19 years hospitalized with a diagnosis code–based definition of sepsis in 2021–2023 using the Transformed Medicai...

A Comparison of Pediatric Hospitalization Data in Cosmos and the Kids’ Inpatient Database

OBJECTIVE: To compare characteristics of pediatric hospitalizations in Epic Cosmos, an electronic health record-based database that aggregates voluntarily submitted data from across the United States, with nationally representative pediatric inpatient data in the Kids' Inpatient...

Beyond Survival: Outpatient Treatment for Functional Recovery After Brain Injury

Abstract Acquired brain injuries (ABIs), including hypoxic-ischemic and traumatic injuries, are leading causes of long-term disability in children. While acute treatment has advanced, many survivors face persistent cognitive, emotional, and physical challenges that require coordi...

Impact of Response to Hypomethylating Agent‐Based Therapy on Survival Outcomes in the Context of Baseline Clinical‐Molecular Risk and Transplant Status in Patients With Higher‐Risk Myelodysplastic Syndromes/Neoplasms: An analysis From the International Consortium for MDS (icMDS)

Baseline IPSS-M risk, response to hypomethylating agent (HMA) therapy, and receipt of allogeneic stem cell transplant (allo-HCT) have all been individually shown to impact overall survival (OS) in patients with myelodysplastic syndromes (MDS). However, the prognostic impact of re...

Consensus-based eligibility criteria and component definitions for neonatal and infant enhanced recovery pathway: a multidisciplinary delphi study

Abstract Objective The 2020 Enhanced Recovery After Surgery (ERAS®) guidelines for neonatal intestinal surgery have not been widely implemented due to unclear eligibility criteria and poorly defined components. We sought to establish consensus-based eligibility criteria and defin...

State of oral innate immunity and salivary microbiome with allogeneic hematopoietic stem cell transplant

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the use of chemotherapy and antibiotics cause large changes in the gut and oral microbiomes. In patients, these differences in the oral microbiome may be related to the re-establishment of the innate immunity in t...

Bridging Practice and Publication: Reexamining Quality Improvement in Pediatric Scholarship

Quality improvement (QI) publication rates in pediatrics surged through the early 21st century yet have noticeably plateaued since that time, a paradoxical shift given the volume of ongoing improvement work across pediatric health systems. We propose that the gap lies not in the...

Associations of Fatherhood and Race With Cardiovascular Health Among Men: Findings From the Coronary Artery Risk Development in Young Adults (CARDIA) Study, 1985‒2022, United States.

. 2026;116(8):1146-1155. https://doi.org/10.2105/AJPH.2026.308439).