RIKEN Center for Brain Science

Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection

The detection of unexpected sounds, or auditory deviance detection, is thought to be achieved by comparing prediction signals and sensory inputs in the auditory cortex. This process is markedly impaired in patients with schizophrenia. However, the local circuit properties underly...

Cryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV delivery

Abstract Tauopathies are characterized by the accumulation of abnormally phosphorylated tau filaments, with disease-specific folds revealed by cryo-electron microscopy (cryo-EM). Here, we delivered a recombinant human tau carrying the P301L/S320F double mutation into App NL-G-F /...

Language-like statistical structure arises in learned signaling: evidence from birdsong

All languages have statistically coherent subsequences (e.g., words) whose frequency distribution follows a power law. These properties facilitate language learning in humans, making them good candidates for arising through cultural transmission as a way to help faithful transmis...

Neural Assimilation and Accommodation in Trilinguals: An fMRI Study at 7 T

Understanding how multiple languages are represented in the multilingual brain is critical to theories of multilingual assimilation and accommodation. Whether a second language (L2) recruits native-like networks (assimilation) or engages additional neural resources (accommodation...