RIKEN Center for Advanced Intelligence Project

Generalizing molecular design via flexible search space control

Abstract Recent advances in generative artificial intelligence have made in silico molecular design a powerful approach for exploring chemical space toward specific goals. However, despite the need for trial-and-error adjustment of generative strategies and reward formulations, m...

Strong connections of locally clustered neurons in the upper-layer cortex underlie schizophrenia-related auditory deviance detection

The detection of unexpected sounds, or auditory deviance detection, is thought to be achieved by comparing prediction signals and sensory inputs in the auditory cortex. This process is markedly impaired in patients with schizophrenia. However, the local circuit properties underly...

dd-RCMA-ES: CMA-ES with Projection-Based Restricted Covariance Matrix Adaptation for High-Dimensional Problems

This paper addresses the computational challenges of the covariance matrix adaptation evolution strategy (CMA-ES) in high-dimensional optimization of an objective function \(f:\mathbb{R}^{n}\to\mathbb{R}\) where \(n\gg 100\) , particularly for problems exhibiting sparse-sensitivi...

Evidence for latent regularities in echolocation-guided flight behaviour of bats

Abstract Echolocating bats navigate complex environments with remarkable agility, yet it remains unclear whether their flight trajectories are governed by reproducible internal policies shared within a species and across the controlled environments examined. To address this quest...

Visualizing diagnosis-associated AMPA receptor-related [11C]K-2 PET SUVR patterns across psychiatric disorders using weakly supervised UMAP

AMPA receptors (AMPARs) mediate fast excitatory neurotransmission and play a central role in synaptic function, with accumulating evidence in psychiatric disorders. Using [ 11 C]K-2 PET to assess AMPAR-related signals in vivo, we examined whether regional standardized uptake valu...

Potential EnergySurfaces of Environment-SensitiveFlapping Fluorophores: FLAP

Abstract A series of FLAP molecules are one of the functional fluorescent probes that can sense subtle changes in local environments such as viscosity, polymer free volume, and external mechanical force. In this work, potential energy surfaces (PESs) of a representative Flexible...