Institution
RIKEN BioResource Research Center
Recent research
- BiologyOpen access
A CRC–MYB chromatin loop controls auxin-mediated nectary growth in Arabidopsis
Abstract Floral nectaries, typically located at stamen bases, secrete sugar-rich nectar containing diverse secondary metabolites. Despite their defined position and specialized function, the mechanisms governing nectary formation remain unclear. Using publicly available single-nu...
- BiologyOpen access
PhAGE Enables One-Step Genome Integration of Large DNA Fragments in Escherichia coli
Abstract Escherichia coli is a well-established model organism in molecular biology and biotechnology. Despite its long history as a laboratory workhorse, the efficient single-step chromosomal integration of large DNA fragments remains a challenge. Currently known methods are eit...
- Engineering & TechnologyOpen access
Recent phylogenomic analyses revealed that the genus Methanobrevibacter , which consists almost exclusively of representatives from the intestinal tract of animals, is severely underclassified. Based on the large relative evolutionary divergence between individual subclades, memb...
- BiologyOpen access
METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth
ABSTRACT Histidine methylation is an evolutionarily conserved but poorly understood post‐translational modification. METTL18 is known to catalyze histidine N τ‐methylation in vitro, yet its physiological functions in mammals remain unclear. Here we show that mouse METTL18 possess...
- Health & MedicineOpen access
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...