Research Institute for Tropical Medicine

Multiplex LAMP-LFA for rapid field-compatible detection of environmental DNA from Schistosoma japonicum and Oncomelania hupensis quadrasi

Abstract This study developed a field-adaptable multiplex Loop-Mediated Isothermal Amplification combined with Lateral Flow Assay (mLAMP-LFA) for simultaneous detection of Schistosoma japonicum and its intermediate host, Oncomelania hupensis quadrasi , in freshwater environments...

Comparative cost analysis of community-based tuberculosis screening: Computer-Aided Detection (CAD) alone versus CAD with point-of-care C-reactive protein testing in South Africa and Lesotho

Community-based active case finding (ACF) for tuberculosis (TB) is recommended in high-burden settings, yet evidence on implementation costs from prospective programmatic data remains limited. We estimated and compared the costs of two community-based ACF screening approaches: Co...

Methenamine, minocycline, metronidazole and pristinamycin (M3P) for multi-drug-resistant Mycoplasma genitalium urethritis: A case series

Objectives Worldwide, Mycoplasma genitalium infections are becoming more resistant to both macrolides and fluoroquinolones - termed multi-drug-resistant (MDR) infections. Combination therapy has shown promise in treating other MDR pathogens. We have previously reported the first...

Invasive Pseudosuccinea columella enters the transmission cycle of an amphistome parasite infecting African buffalo

Abstract Parasite transmission and disease outcomes in African wildlife are increasingly shaped by anthropogenic environmental change, yet empirical data linking parasites, intermediate hosts and wildlife health remain scarce. Following an unexplained increase in mortality among...

Understanding zoonotic spillover interfaces for the design of a One Health education intervention: a qualitative baseline study from rural Thailand

Abstract Background Prevention of zoonotic spillover requires an understanding of how human, animal, and environmental interactions shape risk in everyday life. Efforts have focused largely on surveillance and response rather than on primary prevention informed by lived experienc...