Research Foundation For Mental Hygiene

Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons

The association of cues with the absence or presence of danger is crucial to survival. The synaptic changes that enable association with the absence of danger are unknown, but a role for the tail of the striatum (TS) has been implicated. To investigate this, we conditioned mice t...

Dysregulated adult hippocampal neurogenesis in major depressive disorders

Major depressive disorder (MDD) is associated with reduced hippocampal volume, altered connectivity and negative memory bias, suggesting disrupted hippocampal plasticity. Dysregulated adult hippocampal neurogenesis is a potential contributor, but its relevance in humans and role...