Regione Campania

Medication Complexity and Insomnia Severity in Psychiatric Outpatients: A Moderation Analysis Across Mood and Non-Mood Disorders

Background: Insomnia is common and occurs across psychiatric diagnoses. A prior analysis of this outpatient cohort found that psychotropic medication complexity was associated with insomnia severity, but whether this association is stronger in particular diagnostic groups was not...

Browser-Native Federated Inference on Existing Italian SSN Clinical Workstations: A Peer-to-Peer Sovereignty-Preserving AI Architecture for Italian Regional Health Networks

Clinical adoption of large language models (LLMs) in public healthcare faces a structural impasse: the capital expenditure of centralised high-performance computing on one side and the privacy risk of routing patient data through third-party cloud interfaces on the other. Italian...

CLDN18 as a novel junctional biomarker enhancing multi-gene classification of pancreatic cancer

Pancreatic adenocarcinoma (PAAD) remains one of the most lethal cancers, largely due to the lack of reliable diagnostic biomarkers. Through integrative transcriptomic and proteomic analyses, we evaluated a four-gene signature comprising CLDN18, CEACAM5, FUT3, and FUT6, capable of...

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability

PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), is one of the most frequently altered oncogenes in human cancer and a major driver of tumor initiation, progression, metastasis, and therapeutic resistance. Over the past two decades, advances...

Cognitive rehabilitation with immersive virtual reality in schizophrenia: A randomized waiting list-controlled study

Background Cognitive symptoms represent a major determinant of long-term disability in chronic schizophrenia and only partially respond to pharmacotherapy. Evidence is growing about the potential effect of cognitive interventions to promote functional recovery. Immersive virtual...