Regional Medical Center

Summary of Research: HER2CLIMB-05: A Phase III Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-Line Maintenance Therapy for HER2+ Metastatic Breast Cancer

This is a summary of a research article reporting the findings of the HER2CLIMB-05 trial (NCT05132582), a randomized, double-blind, placebo-controlled, international, phase III trial. The HER2CLIMB-05 trial was conducted to compare the efficacy and safety of adding tucatinib vers...

Marketing Beyond Broadening: Boundarying and the Cumulative Development of Marketing Theory

Marketing's broadening has enabled the discipline to engage diverse phenomena, but it has also created a theoretical problem: empirical relevance does not necessarily constitute a marketing contribution. This commentary identifies this theoretical dilemma as the Broadening Parado...

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

ABSTRACT Cell therapy combined with biomimetic polymer engineering offers a promising strategy for cardiovascular regeneration. Compartmentalizing single cells in hydrogels creates three‐dimensional (3D) micro‐niches that enhance bio‐responsiveness and the therapeutic efficacy of...

Novel Lipoprotein (a) Therapies: A Comprehensive Review

Abstract Purpose of Review Lipoprotein(a) [Lp(a)] is a genetically determined, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Plasma Lp(a) levels are 70–90% heritable, largely unresponsive to lifestyle changes, and poorly co...