Regenerative NanoMedicine

Prognostic performance of the systemic immune-inflammation index in hospitalized patients with COVID-19: a multicenter emergency department study

Abstract Introduction The systemic immune-inflammation index (SII) has been proposed as a simple prognostic biomarker in COVID-19, but its performance relative to routinely available inflammatory markers and its incremental value beyond clinical predictors remain uncertain. We ev...

STABILOOP, a cohort trial to assess automated insulin delivery in the management of patients living with type 1 diabetes who are eligible for islet transplantation

A limited subset of people living with type 1 diabetes (T1D) is affected by extreme glycemic lability and frequent unpredictable severe hypoglycemia, significantly impairing quality of life and associated with higher morbidity, mortality, and healthcare costs. Islet transplantati...

Renal Resistive Index Responsiveness to a Mean Arterial Pressure Test As a Guide for Mean Arterial Pressure Target in the Early Phase of Septic Shock: A Physiological Study

OBJECTIVES: Guidelines recommend targeting a mean arterial pressure (MAP) greater than or equal to 65 mm Hg in septic shock. Although experts advocate for individualized targets, no validated bedside tool exists. An increased renal resistive index (RRI) is associated with acute k...